The article focuses on the relationship of wound healing process with that of breast cancer. In some breast cancers, a set of genes involved in wound healing show distinct expression profiles, and these wound-response signatures can help predict the long-term health of patients. Previous work ...
HER2.This test looks for the gene human epidermal growth factor receptor 2. It can help cancer grow more quickly. If your cancer isHER2-positive, targeted therapy could be a treatment option for you. Grade.This tells the doctor how different the cancer cells look from healthy cells and wheth...
Intravenous liposomal irinotecan in metastatic triple-negative breast cancer after ≥ 2 prior lines of chemotherapy: a phase Ib study Cytotoxic chemotherapy remains the standard treatment for triple negative breast cancer (TNBC), an aggressive subtype of breast cancer associated with poor prognosis. Her...
Breast cancer is the most common cancer in women diagnosed in the U.S. and worldwide. Obesity increases breast cancer risk without clear underlying molecular mechanisms. Our studies demonstrate that circulating adipose fatty acid binding protein (A-FABP,
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Occasionally, the treatment of breast cancer requires the removal of the breast while also leaving a large chest skin deficit. Especially if radiation has been done or is planned, the best way to restore the missing skin to preserve its essential function would be by the use of a vascularized...
The tumour immune microenvironment is shaped by the crosstalk between cancer cells, immune cells, fibroblasts, endothelial cells and other stromal components. Although the immune tumour microenvironment (TME) serves as a source of therapeutic targets, it
Determine the stage of the cancer and whether additional treatment is necessary. Treat the cancer locally. Surgery is local therapy that can remove cancer cells in or near the breast but cannot treat breast cancer cells that have spread to other locations in the body. Cancer cells that have sp...
Novel treatment strategies are urgently needed, especially in the setting of metastatic disease where outcomes are still dismal. The breast cancer microenvironment is a complex mixture of cells, the proteins they secrete, and the ECM in which they reside. Alterations within the microenvironment are ...
For example, IL-1 is released by effector cells and plays a central role in immune and inflammatory responses in breast cancer, specifically tumor invasion.34 Preclinical studies of treatment with the IL-1 receptor antagonist anakinra promoted significant breast tumor control in mice. A pilot study...