Again from the Press release Professor Stephen Duffy, Cancer Research UKs professor of cancer screening, said: this large study means we can now say for certain that this system is as good at detecting breast cancer as the one used as standard practice Laboratory tests show promise for beating...
Association analysis identifies 65 new breast cancer risk loci, predicts target genes for known risk loci and demonstrates a strong overlap with somatic driver genes in breast tumours. Genome-wide association studies for breast cancer have identified com
Tibor Tot has given me an unusual opportunity via his request to summarize my work in computed tomography (CT), which indeed since 1977 has been directed toward eliminating the scourge of breast cancer via search and destroy of premetastasis tumors, inst
The 313-variant polygenic risk score (PRS313) provides a promising tool for clinical breast cancer risk prediction. However, evaluation of the PRS313 across different European populations which could influence risk estimation has not been performed. We e
Audit of screening performance should reflect appropriate population targeting. Methods: An observational study on consecutively screened high-risk women, assessment of the contralateral breast staging a new cancer, or surveillance in women with prior breast cancer or high-risk lesion in Perth, Western ...
Breast cancer susceptibility variants frequently show heterogeneity in associations by tumor subtype1,2,3. To identify novel loci, we performed a genome-wide association study including 133,384 breast cancer cases and 113,789 controls, plus 18,908 BRCA1 mutation carriers (9,414 with breast cancer...
Martin RM, Gunnell D, Owen CG et al (2005) Breastfeeding and childhood cancer: a systematic review with meta-analysis. Int J Cancer. 117:1020–31 CASPubMedGoogle Scholar Klement E, Cohen RV, Boxman J et al (2004) Breastfeeding and risk of inflammatory bowel disease: a systematic review...
Statutory State-based cancer registries are considered the ‘gold standard’ for researchers identifying cancer cases in Australia, but research using self-report or administrative health datasets (e.g. hospital records) may not have linkage to a Cancer Registry and need to identify cases. This stud...
Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK Kyriaki Michailidou, Manjeet K. Bolla, Qin Wang, Joe Dennis, Paul D. P. Pharoah & Douglas F. Easton Department of Electron Microscopy/Molecular Pathology, The Cyprus Insti...
We analysed rare CNVs in genes and non-coding regions for 86,788 breast cancer cases and 76,122 controls of European ancestry with genome-wide array data. Gene burden tests detected the strongest association for deletions in BRCA1 (P = 3.7E−18). Nine other genes were associated ...