Breast cancer is the second most common type of cancer worldwide, with a high prevalence and mortality rate among females globally. It is classified into various types and subtypes based on its molecular and cellular characteristics. Additionally, both genetic and nongenetic risk factors have been i...
Breast cancer riskHistopathologyNatural language processingTo characterize associations of microcalcifications (calcs) with benign breast disease lesion subtypes and assess whether tissue calcs affect risks of ductal carcinoma in situ (DCIS) and invasive breast cancer (IBC).#We analyzed detailed ...
monoallelic mutations have been found to be associated with breast cancer risk, while the risk associations of others remain unknown. The gene for FA type C,FANCC, has been proposed as a breast cancer susceptibility gene based on epidemiological and sequencing...
28,29,30. Our previous study found that breast cancer cells can secrete factors to regulate gene expression profiles and epigenetic changes in surrounding WBCs, especially gene-containing long interspersed element 1 (LINE-1)27. Mucin 1 (MUC-1)-positive plasma...
Breast cancer is the most common malignancy among women worldwide, characterized by complex molecular and cellular heterogeneity. Despite advances in diagnosis and treatment, there is an urgent need to identify reliable biomarkers and therapeutic targets
With the increasing incidence of breast lesions, the differential diagnosis between benign lesions and breast cancer (BCa) has become a big challenge. Host peripheral blood mononuclear cells (PBMCs) could undergo changes in DNA methylation upon disease progression. However, the clinical value of DNA...
Breast cancer frequently metastasizes to the skeleton, interrupting the normal bone remodeling process and causing bone degradation. Osteolytic lesions are the end result of osteoclast activity; however, osteoclast differentiation and activation are mediated by osteoblast production of RANKL (receptor activat...
On the other hand, it has been suggested that the (-938C > A) polymorphism could serve as a survival prognosticator as well as high-risk indicator within the lymph node-negative breast cancer [22]. In order to investigate whether BCL-2 (-938C > A) genotype can serve as a susceptible...
The primary objective of this investigation is to delve into the involvement of the long noncoding RNA (lncRNA) SPACA6P-AS in breast cancer (BC) developmen
Breast cancer (BC) risk for BRCA1 and BRCA2 mutation carriers varies by genetic and familial factors. About 50 common variants have been shown to modify BC risk for mutation carriers. All but three, were identified in general population studies. Other mutation carrier-specific susceptibility varian...