During the past several years we have conducted extensive studies on the role of degradative enzymes in the invasion and metastasis of breast cancers. We found that only a few enzymes were implicated in the invasion of human breast cancer cells, such as heparanase and type IV collagenolytic ...
New molecular insights challenge the traditional model of metastasis, and indicate that the metastatic capacity of breast tumours is an inherent feature, and not necessarily a late, acquired phenotype. Local breast cancer might have a 'non-metastatic, good-prognosis' stem cell of origin; metastasizin...
To investigate any rational relation between breast cancer metastasis to various organs, a comprehensive comparison ran among the common upregulated hub genes designated to have a critical role in primary and bone-metastatic breast cancer and the hub genes which were responsible for breast cancer metas...
There is no established method for assessing the prognosis of patients with breast cancer and metastasis confined initially to bone. The medical records of 82 patients with breast cancer nad metastasis confined initially to bone were reviewed. The following variables were analyzed at the time when bo...
Histological grading, when adequately carried out, provides a simple, inexpensive, and highly accurate method for assessing tumor biological characteristics and patient prognosis. This is of particular importance for breast cancer patients in parts of the world where access to new molecular technology is...
Lymph node micrometastasis is an important prognostic factor in breast cancer, but patients with different numbers of involved lymph nodes are all divided into the same N1mi stage without distinction. We designed this study to compare the prognosis and local treatment recommendations of N1mi breast ...
stability. Further investigation of USP20 demonstrated its function in promoting migration, invasion, and metastasis of breast cancer. USP20 positively correlates with SNAI2 protein level in breast tumor samples, and higher USP20 expression is associated with poor prognosis in ER- breast cancer ...
Cancer Discov. 2, 401–404 (2012). Article Google Scholar Györffy, B. et al. An online survival analysis tool to rapidly assess the effect of 22,277 genes on breast cancer prognosis using microarray data of 1,809 patients. Breast Cancer Res. Treat. 123, 725–731 (2010). Article ...
Pellino-1 (PELI1) is an E3 ubiquitin ligase acting as a key regulator for the inflammation and autoimmunity via the ubiquitination of the substrate proteins. There is increasing evidence to support that PELI1 functions as an oncoprotein in tumorigenesis
metastasis in patients with breast cancer.In subgroup analysis,we found that breast cancer patients with type-2 DM had a worse prognosis compared with those without type-2 DM in subgroup populations with involved lymph nodes or with any status of ER.It was interesting that in breast cancer ...