The efficacy of cancer immunotherapy relies on the sufficient functional immune cells recruited. Here this group designs an abemaciclib-loaded supramolecular peptide hydrogel achieving sustained release after intratumoral injection to effectively induce cancer cell death and increase IL-2 secretion, thereby ex...
The analysis of surface membrane and intracellular antigens in breast carcinoma cells has been greatly accelerated by the discovery of monoclonal antibodies produced by somatic cell hybridization1. Such antibodies provide a large supply of a reagent whic
Today, it is estimated that one woman out of every nine in the USA will develop breast cancer sometime during her lifespan. The breast cancer problem is reflected in the estimates below, of breast cancer incidence in the USA (derived by theAmerican Cancer Societyfrom government data). The n...
Gremlin-1 (GREM1), one of the bone morphogenetic protein antagonists, is involved in organogenesis, tissue differentiation and kidney development. However, the role of GREM1 in cancer progression and its underlying mechanisms remain poorly understood. Th
Breast Cancer Research 25(S1): O2 Aim: to investigate whether breast density is a predictor for subsequent events in patients with screen-detected DCIS, taking other factors into account. Cohort and Exclusions: Patients entered into the Sloane trial with screen-detected DCIS (between 1 April 2003...
These drugs are made of a radioactive substance. You take the drug as an injection into a vein or artery, or you swallow it, and it gives off radiation and kills cancer cells. Side effects: Fatigue Skin issues, such as itchiness, redness, peeling, or blistering ...
In nude mice bearing a human gastric- or head-and-neck cancer cell line xenograft, 89Zr-DN30 injection resulted in a maximum tumor to blood ratio of 5 (Perk et al., 2008). Anti-HGF nanobodies (1E2-Alb8 and 6E10-Alb8) were labeled with 89Zr and used as a PET tracer in nude ...
intramuscular injection as opposed to an orally administered antiestrogen like tamoxifen. This drawback has led to the development of newer orally bioavailable SERDs, some of which are currently being tested in early phase I and II clinical trials for the management of ER-positive breast cancer [...
Breast cancer is the most prevalent cancer worldwide, and metastasis is the leading cause of death in cancer patients. Human monocyte chemoattractant protein-1 (MCP-1/CCL2) was isolated from the culture supernatants of not only mitogen-activated peripher
It is usually given as an injection into a vein or as a topical cream. It is a part of the class of drugs known as anti-metabolites, which interfere with the synthesis and function of DNA and RNA in rapidly dividing cancer cells, leading to their destruction16. In breast cancer ...