The presence of estrogen receptors (ERs), as detected by immunohistochemistry (IHC), is a weak prognostic marker of clinical outcome in breast cancer, but a strong predictive marker for response, for example, to tamoxifen-based therapy. As with all IHC markers, factors such as tissue fixation ...
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IHC was used to detect CD44/CD24, ALDH1A1, aldehyde dehydrogenase family 1 member A3 (ALDH1A3) and integrin alpha-6 (ITGA6). A 'Total CSC' score representing expression of all four CSC markers was also investigated. Association with breast cancer specific survival (BCSS) at 10 years was...
HRA has extensive experience in interpreting IHC in breast cancer TMAs, with Kappa agreement statistics of 0.81, 0.88 0.65 and 0.85 for the markers aurora kinase a (AURKA), Trans-acting T-cell-specific transcription factor GATA-3 (GATA3), mast/stem cell growth factor receptor kit (c-Kit) ...
Cancer stem cells (CSC)Indian breast cancerCancer stem cells (CSC) are a small number of tumour propagating cells present in the bulk of tumour cells. Expression of biological markers for CSCs viz. cluster of differentiation 24 and 44 (CD24, CD44) and aldehyde dehyodeganse 1 (ALDH1) ...
病理学完全缓解(pCR)定义为NAC后手术标本ypT0/is和ypN0。排除HER2 扩增的eBC患者(IHC 3+,或FISH 2+伴有扩增)。根据确诊时病理活检报告确定HER2状态。HER2低表达定义为IHC 1+或2+,且FISH检测阴性。 研究结果 研究共纳入511例eBC患者...
A Representative SEC16G immunohistochemical (IHC) with different scores based on staining intensity in breast cancer tissue microarray. B Representative SEC61G IHC staining in breast cancer tissues and adjacent non-tumor normal tissues. C Comparison of IHC staining score distributions between breast cance...
(intense) and quantitatively scored for proportion positive cancer cells. Proportion score 0 represented less than 1% positive cells, 1: 1–10%, 2: 11–50%, and 3: 51–100%. Based on IHC intensity and proportion of positive cells each tumour sample was grouped as negative (less than 1% ...
Gene amplification is a frequent alteration in breast cancer (BC) that affects multiple genomic regions [1–3]. One of the most studied amplifications is located in chromosomal region 17q12 and involves the ERBB2 gene. ERBB2 encodes a transmembrane tyrosine kinase receptor of the ERBB/EGFR fami...
In total, we obtained 87 FFPE breast carcinomas that had previously been scored for the breast cancer markers, ER, PR and HER2 by immunohistochemistry (IHC) according to guidelines based on the ASCO/CAP recommendations for ER, PR and HER2 testing (ER/PR testing (http://www.cap.org/apps/...