The article reports that two recent studies associate estrogen use with at least a modest increase in breast cancer risk. In one, researchers at the University of Southern California School of Medicine, Los Angeles, concluded tha...
An estrogen-receptor positive cancer thrives on estrogen (and does not grow without it). Estrogen blood levels of women who had breast cancer recurrence were twice as high as those whose breast cancer had not returned, the researchers reported. Rock and team said that the next step is to ...
Breast cancer is a multifactorial disease. A spectrum of internal and external factors contributes to the disease promotion such as a genetic predispositio
Transcriptional activation of estrogen receptor alpha in human breast cancer cells by histone deacetylase inhibition. Cancer Res. 60, 6890–6894 (2000). CAS PubMed Google Scholar Richon, V.M., Sandhoff, T.W., Rifkind, R.A. & Marks, P.A. Histone deacetylase inhibitor selectively induces ...
American Joint Committee on Cancer CI: confidence interval EQA: external quality assurance ER: estrogen receptor EU: European Union GGI: genomic grade index HR: hazard ratio LN: lymph node NCB: needle core biopsy NGS: Nottingham Grading System NPI: Nottingham Prognostic Index NST:...
Approximately 70% of invasive breast cancers express estrogen receptor (ER), and the majority of ER positive cancers also express progesterone receptor (PgR). Although the presence of normal PgR levels suggests an intact ER signal transduction pathway in breast cancer cells, discrepant ER and PgR ...
If yourbreast cancerhas a significant number of receptors for either estrogen or progesterone, it’s considered hormone-receptor positive. Tumors that are ER/PR-positive are much more likely to respond to hormone therapy than tumors that are ER/PR-negative. ...
Excessive intake of high-protein, high-fat foods can cause elevated estrogen levels and increase the risk of breast cancer. The risk of breast cancer among obese people is 1 to 1.5 times higher than that of people with normal weight, and the risk of breast cancer spreading is 2 times highe...
Epidemiological studies31 and clinical trial32 have suggested that a high fiber intake was related to reductions in blood levels of estrogen. Recent study has indicated that higher preoperative serum estrogen level had a negative prognostic effect in postmenopausal women with breast cancer, especially ...
The Basal-like breast cancer is largely untreatable because the tumor cells are usually lacking the estrogen receptor, progesterone receptor, and HER2 protein that are the main therapeutic targets for other forms of breast cancer. The researchers from Zhejiang University School of Medicine examined over...