Genes were identified using two different detection methods (cDriver and MutSigCV;n = 13). Breast cancer drivers not detected due to insufficient statistical power (n = 173 independent tumors) but frequent in this dataset (≥2%) were also added to the overall list of drivers of bre...
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can prevent the global change in open chromatin architecture that accompanies DTP state formation during PI3K/mTOR inhibitor response. Moreover, combination of PI3K/mTOR and BET inhibitors drives complete cell kill of basal-like breast cancer cell lines (BCCLs) in vitro, and...
Subterranean blind mole rat, Spalax, has developed strategies to withstand cancer by maintaining genome stability and suppressing the inflammatory response. Spalax cells undergo senescence without the acquisition of senescence-associated secretory phenotype (SASP) in its canonical form, namely, it lacks ...