When a combined regimen proved to be effective, one agent from the combination with better safety profile and more convenient usage could be chosen as the maintenance therapy. For patients who cannot tolerate maintenance chemotherapy, their treatment can be discontinued. These patients should be ...
Kaiser Permanente Washington, we present the changes in chemotherapy regimens over time, and explore use of NCCN-guideline regimens (GR), guideline regimens used when said regimens were not included in guidelines, referred to as time-discordant regimens (TDR), and non-guideline regimens (NGR)....
Chemotherapy medicinesare used to kill cancer cells. You may receive one medicine or a combination of medicines. Inhibitor medicinesmay be given to help destroy the cancer cells. One medicine helps your immune system kill the cells. Another medicine makes the cells die by preventing them from bei...
For patients with a high risk of recurrence (e.g., positive lymph nodes), dual-targeted therapy with trastuzumab and pertuzumab combined with adjuvant chemotherapy is recommended (the commonly used chemotherapy regimen is anthracycline followed by taxane EC-P, or taxane combined with carboplatin TCb...
Amat and colleagues [49] reported that assessment of grade on needle core biopsy (NCB) is a strong predictive factor of response to induction chemotherapy in breast cancer, independently of the type of regimen used. Therefore, despite the limitations associated with the accuracy of grading core ...
The regimen has been used extensively in the Netherlands, mainly in breast cancer and germ cell cancer.CTC has been employed in 2 randomized studies of high-dose chemotherapy in breast cancer. The first was a randomized phase 2 single-center study in 81 patients that did not show ...
Breast cancer chemotherapy generally seems to be well tolerated by the fetus in the second and third trimesters, at least in terms of serious adverse outcomes that are apparent in infancy, if premature delivery can be avoided (Abdel-Hady 2012, Loibl 2012a) (see the individual medications ...
The impact of HIV infection on neoadjuvant and adjuvant chemotherapy relative dose intensity in South African breast cancer patients. Oncologist. 2023;28(10):e921-e929. doi:10.1093/oncolo/oyad056 PubMedGoogle ScholarCrossref 22. von Elm E, Altman DG, Egger M, Po...
If a regimen of HER2-targeting therapy and chemotherapy is started, ET may be added to the HER2-targeted therapy when chemotherapy ends [51,52] (LC low; GR C). Treatment of triple-negative advanced breast cancer TNBC is characterized by the absence of expression of ER, PR, and HER2. TNB...
According to NCCN guidelines, the combination regimen of chemotherapy plus anti-HER2 drugs is regarded as the standard treatment regimen for HPBC patients. Although patient survival has been markedly prolonged by treatment with anti-HER2 drugs7, HPBC patients still face lack of optimal subsequent tre...