The objectives are as follows: The objective of this review is to compare the effects on survival and quality of life of shorter with longer durations of chemotherapy in women with metastatic breast cancer. This will include: a) shorter vs longer duration of the same drug regimen (eg 6 ...
Single agent chemotherapy is clearly effective in causing tumor regression, but effective combination chemotherapy provides more responses and a longer duration of response. The most effective combination regimens at present contain doxorubicin. Pharmacologic studies at the cellular level can be expected to ...
chemotherapy regimen, thereby prolonging treatment duration; n=11 000), double (ie, strongly confounded trials in which the effects of adding four separate cycles of a taxane to an anthracycline-based regimen were counterbalanced in controls by roughly doubling the number of cycles of non-taxane...
Triple-negative breast cancer (TNBC) is the most malignant subtype of breast cancer (BC) with a poor prognosis. Current treatment options are limited to surgery, adjuvant chemotherapy and radiotherapy; however, a proportion of patients have missed the surgical window at the time of diagnosis. TNBC...
During a client's chemotherapy regimen for breast cancer, which is important for the nurse to include in her plan of care A.Instruct the client to consume plenty of raw fruits and vegetables.B.Take rectal temperatures for greater accuracy.C.Tell the client to avoid crowds and infected individu...
The UK TACT study (CRUK01/001) investigated whether sequential docetaxel after anthracycline chemotherapy would improve patient outcome compared with standard chemotherapy of similar duration. Methods In this multicentre, open-label, phase III, randomised controlled trial, 4162 women (aged >18 years...
Local hypoxia is a common feature of many solid tumors and may lead to unsatisfactory chemotherapy outcomes. Anaerobic bacteria that have an affinity to hypoxic areas can be used to achieve targeted drug delivery in tumor tissues. In this study, we devel
(n=1), respectively. Collectively,ER− and PR− breast cancer patients were likely to benefit more from TP regimen than TA, TAP, and anthracycline-based chemotherapy. Notably, some studies combined their report of ER and PR as hormone receptors (HR). Analysis of HR+ and HR− patients...
Abstract Importance Trastuzumab plus chemotherapy is the standard adjuvant treatment for patients with human epidermal growth factor receptor 2 (HER2)-positive early breast cancer. While the standard duration of trastuzumab treatment is 12 months, the benefits and harms of trastuzumab continued beyond the...
et al. Less efficacy with alternating regimen as adjuvant chemotherapy in stage II node-positive breast cancer: results at 8 years (Pronacam 85). Br J Cancer 76, 545–550 (1997). https://doi.org/10.1038/bjc.1997.423 Download citation Issue Date01 August 1997 DOIhttps://doi.org/10.1038/...