The most common site of metastasis in breast cancer is the bone, where the balance between osteoclast-mediated bone resorption and osteoblast-mediated bone formation is disrupted. This imbalance causes osteolytic bone metastasis in breast cancer, which leads to bone pain, pathological fractures, spinal...
Landys K. Prognostic value of bone marrow biopsy in breast cancer. Cancer 1982; 495 13-5 18.Landys K. Prognosticvalue of bone marrowbiopsyin breast cancer.Cancer 1982;49:513-8.Landys K (1982) Prognostic value of bone marrow biopsy in breast cancer. Cancer 49:513-518...
There is no established method for assessing the prognosis of patients with breast cancer and metastasis confined initially to bone. The medical records of 82 patients with breast cancer nad metastasis confined initially to bone were reviewed. The following variables were analyzed at the time when bo...
Breast cancer frequently metastasizes to the skeleton, interrupting the normal bone remodeling process and causing bone degradation. Osteolytic lesions are the end result of osteoclast activity; however, osteoclast differentiation and activation are mediated by osteoblast production of RANKL (receptor activat...
Bone metastasis is a lethal consequence of breast cancer. Here we used single-cell transcriptomics to investigate the molecular mechanisms underlying bone metastasis colonization—the rate-limiting step in the metastatic cascade. We identified that lymphotoxin-β (LTβ) is highly expressed in tumour ce...
Breast cancer is considered to often involve bone metastasis. Early detection and treatment of bone metastasis are essential in improving the prognosis of this disease. In 47 patients with bone metastasis confirmed with bone scintigraphy... S Tanaka,Y Matsumura,M Tanaka,... - 《Kaku Igaku the ...
Inflammatory breast cancer is a rare but aggressive form of the disease, characterized by rapid swelling, redness, and skin changes. It is often diagnosed at advanced stages, as it typically spreads quickly. Early recognition of symptoms and prompt treatment are crucial for better prognosis. Related...
The prognosis for patients with primary breast cancer involving multiple axillary lymph nodes is poor. Only about 30% of patients remain disease-free at 5 ... DD Hurd,WP Peters - 《Journal of the National Cancer Institute Monographs》 被引量: 34发表: 1995年 Bone Health and Coronary Heart Di...
(ER-/PR-/HER2-; triple negative bone metastasis breast cancer cell line) was characterized, is used for detecting the upregulated and downregulated genes in different breast cancer stages in the first step. In the second step, after exposing two cut-offs, the common DEGs in primary and ...
The prognosis is favorable for women with clinically confined tumors at the time of diagnosis, but mortality rates are greater than 80% in cases where the tumor has metastasized to distant sites [1]. Metastasis to bone occurs frequently in advanced breast cancer and is accompanied by debilitating...