Del Re M, Michelucci A, Simi P, et al (2012). Pharmacogenetics of anti-estrogen treatment of breast cancer. Cancer Treat Rev, 38, 442-50.Del Re M, Michelucci A, Simi P, and Danesi R (2012) Pharmacogenetics of anti-estrogen treatment of breast cancer. Cancer Treat Rev 38:442-450....
Combining the drugs selinexor, which prevents XPO1 anti-cancer proteins from functioning, and 4-OHT, which inhibits estrogen receptors from responding to the hormone, might be more effective than either drug alone, the researchers hypothesized. In the current study, the researchers treated endocrine-...
Acquired tamoxifen resistance in human breast cancer--potential mechanisms and clinical implications. The widespread use of the antiestrogen tamoxifen in the management of breast cancer has resulted in more patients eventually developing acquired resistance... Johnston,RD Stephen - 《Anticancer Drugs》 被...
cell mechanics; breast cancer; estrogen; AFM; viscoelasticity; E-cadherin; confocal microscopy Graphical Abstract1. Introduction Breast cancer is a major cause of cancer-related death for women and, despite all advances, there are still many unresolved research questions and unmet clinical needs [1]...
Mutations inESR1, which encodes estrogen receptor-α (ERα), drive resistance to approved endocrine therapies in breast cancer. We studied the molecular response to the investigational ERα antagonist and degrader, giredestrant, in preclinical models and biopsy samples. We found that long-term inh...
Preclinical data and animal models suggest that, like tamoxifen, raloxifene has potent antiestrogen effects on breast tissue.20 Observation of breast cancer incidence (albeit measured as a secondary end point in osteoporosis studies) showed a statistically significant reduction in the incidence in ...
[33]. Studies conducted in the MCF-7 cell line estrogen receptor-positive cells (ER+) showed that low levels of BPA significantly increased proliferation [30] and induced MCF-7 breast cancer cell proliferation through upregulation of genes that promote the cell cycle and downregulation of anti-...
Estrogen Starvation Promotes TRAIL Induction of Breast Cancer Cells ApoptosisWest China Medical Journal | 2009, 24(4): 923-925 Article Views:3099 PDF Downloads:0 Cited by:0 Authors: WANG Ranran , LIU Dongbo , LUO Ting Keywords: MCF-7; TRAIL; 雌激素饥饿 Export PDF Favorites Scan Get...
As carriers for drug delivery, EVs show potential in transporting therapeutic substances such as nucleic acids, and anti-breast cancer drugs (Table2.[169,170,171,172,173,174,175,176,177,178,179] [180,181]) [182,183]. Furthermore, they can be labeled with tissue-specific receptors and mo...
Estrogen influence on androgen signaling in breast cancer AR+, ER+ cancers Breast tumors that are ER+ are more likely to be AR+ compared to tumors that are ER−67, and AR status is related to ER and PR status but independent of the status of HER268. Interestingly, patients with AR:ER...