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Metaplastic breast cancer is a highly chemoresistant breast cancer subtype with limited therapeutic options. Here, the authors report that the NOS inhibitor, L-NMMA, sensitises metaplastic breast cancer to a selective PI3K inhibitor, alpelisib, and taxane chemotherapy via repression of c-JUN mediated...
Many patients become resistant or tolerant to a wide range of chemotherapeutic drugs; therefore, researchers are digging into personalized medicine for the management of chemotolerance to increase cancer survivors with better quality of life. Recently, various genes/polymorphisms have been explored to be...
The CheckMate-7FL and KEYNOTE-756 trials provide robust evidence for the efficacy of neoadjuvant chemo-immunotherapy in high-risk, early-stage hormone receptor-positive (HER2-negative) breast cancer, and an opportunity to personalize therapy in this population. ...
How long is chemo treatment for breast cancer? Chemotherapy: Chemotherapy is a medical treatment that is used to treat cancer using anti-cancer drugs. The drugs administered inhibit mitosis, or cell division of the cancer cells. One of the side affects is often hair loss, because the drugs us...
In patients with triple-negative breast cancer, ctDNA was most commonly identified within six months after treatment, reflecting the disease’s typical pattern of early recurrence. Top Breast Cancer Stories in 2024 Darlene Dobkowski, MA January 1st 2025 ...
Learn about the breast cancer experience, from symptoms and tests to treatments, recovery, and prevention. Pictures show breast structure and tumors.
A new study adds to the evidence that chemotherapy enhances cancer's spread beyond the primary tumor, showing how one chemo drug allows breast cancer cells to squeeze through and attach to blood vessel linings in the lungs.
+/− indicates with or without; BCS, breast-conserving surgery (i.e., lumpectomy/partial mastectomy, in which only cancerous tissue plus a surrounding layer of normal tissue is removed); chemo, chemotherapy (includes targeted therapy and immunotherapy); mastectomy, surgical removal of the ...
Quality of life issues are becoming crucial considerations for patients with breast cancer, physicians, and researchers. The term ‘chemobrain’ was created to describe cognitive impairments experienced by patients after receiving chemotherapy7,8,9,10,11,12,13. Typical concerns reported by patients ...