al Study Design Initially, a consecutive series of female BRCA1 and BRCA2 mutation carriers were enrolled, who under- went risk-reducing salpingo-oophorectomy (ICD 9-CM code 65.6) at the Department of Gynecology of the University Medical Center Groningen from 1 January 1996 to 1 March 2012....
Although there are differences in the association patterns between BRCA1 and BRCA2 mutation carriers and the general population for several loci, no study has comprehensively evaluated the associations of all known BC susceptibility alleles with risk of BC subtypes in BRCA1 and BRCA2 carriers. ...
The lifetime risk for breast and ovarian cancer rises dramatically for BRCA mutation germline carriers compared to the general population (Figure 1). The overall risk varies by family history, type and location of the mutation, age at diagnosis, parity (number of term pregnancies), environmental ...