When evaluating whether the known breast cancer susceptibility loci identified through population based studies also modify breast cancer risk in mutation carriers, a significance threshold ofP<0.05 was used because of the strong prior evidence of association for these loci with disease risk. For the a...
” were evaluated for any evidence of personal or family histories of HBOC-related cancers, through extraction of International Classification of Diseases (ICD)-9 and ICD-10 codes from participant EHRs (Additional file1: Table S1). These data were supplemented by participant questionnaire ...
The overall risk varies by family history, type and location of the mutation, age at diagnosis, parity (number of term pregnancies), environmental factors, and genetic modifiers [5–10]. The discovery of the hereditary breast and ovarian cancer (HBOC) BRCA genes in the early 1990s laid the ...