Breast cancer riskEarly detectionAge limit for breast cancer surveillanceBRCA1SURVEILLANCEOVARIANRISKSPurpose A semi-annual surveillance scheme from age 25 to 30 years is offered to BRCA1/BRCA2 pathogenic sequence variants (PSVs) carriers for early detection of breast cancer (BC). There is a ...
This cohort study estimates age-specific risks of breast, ovarian, and contralateral breast cancer among carriers of BRCA1 and BRCA2 mutations and
IN Western Europe and the United States approximately 1 in 12 women develop breast cancer. A small proportion of breast cancer cases, in particular those arising at a young age, are attributable to a highly penetrant, autosomal dominant predisposition to the disease. The breast cancer susceptibility...
Shimotsuma Department of Endocrine Surgery, Kawasaki Medical School, Kurashiki, Japan 43 Introduction Breast cancer is one of the most common malignancies among women, and its cumulative risk by age 85 is 1 in 8 women in the United States and 1 in 40 women in Japan (Newman et al. 1988; ...
BRCA2-mutated carriers have a high lifetime risk of breast cancer (BC), an early age of onset, and an increased risk of other cancers (including ovarian, pancreatic, and prostate cancer). Almost 70–80% of BRCA2-mutated BC are estrogen receptor (ER)-positive, which is a particular type...
Management of the high-risk patient Because both BRCA1 and BRCA2 are autosomal genes, they can be carried and transmitted by men in the affected families. BRCA2, which localizes to chromosome 13, confers risks for breast and ovarian cancer in women similar to those conferred by BRCA1; unlik...
For BRCA1 and BRCA2 carriers who underwent risk-reducing salpingo-oophorectomy at age 40 years, the cumulative risk of breast cancer was 49.7% and 52.7%, respectively, by 70 years. Meaning Risk-reducing salpingo-oophorectomy was associated with a reduction in breast cancer risk for women ...
Objective: Female carriers of BRCA1/BRCA2 mutations (BRCAm) are at increased risk of developing breast and ovarian cancer. The main prevention options currently available consist in either clinical-radiological surveillance or risk-reducing surgery. This study investigated factors which might influence ...
risk of developing breast cancer, including options for screening and prophylactic surgery.BRCA1andBRCA2carriers are recommended to undergo prophylactic bilateral salpingo-oophorectomy by age 35–40 years or when childbearing is complete. This surgery significantly reduces the risk of ovarian cancer and...
Women who carry pathogenic variants inBRCA1(OMIM 113705) andBRCA2(OMIM 600185) have greatly increased risk of developing breast cancer. Recent cumulative risk estimates in high-risk families for developing breast cancer by age 80 years were 72% (95% confidence interval (95% CI, 65–79%))...