27、 in prostate cancerj.current treatment options in oncology,2017,18(6):37.20 przybycinski j,nalewajska m,marchelek-mysliwiec m,et al.poly-adp-ribose polymerases(parps) as a therapeutic target in the treatment of selected cancersj.expert opinion on therapeutic targets,2019,23(9):773-78521...
Breast Cancer BRCA mutation testing can reveal important information about potential treatment options along with patient and familial risk. Discover more Prostate Cancer The ability to investigate, diagnose and manage prostate cancer has been improved significantly by the identification of mutations in BRCA...
The advent of poly(ADP-ribose) polymerase (PARP) inhibitors has revolutionized the therapeutic landscape for cancers associated with gBRCAm, including breast, ovarian, prostate, and pancreatic cancer4. For breast cancer, the focus of this article, PARP inhibitors are approved for early and advanced ...
targeted cancer therapy options, and guidelines for early cancer detection. It also highlighted areas of emerging research and clinical trial opportunities for maleBRCA1/2PV carriers. These developments, along with the continued relevance to family cancer risk and reproductive options, have informed chan...
1. Work with your doctor to find a personalized treatment plan If you have certain types of cancer, knowing yourBRCAstatus may help your doctor find tailored treatment options for you. It may also help when it’s time to make surgical and chemotherapy decisions. ...
Box 1. Characteristics that should trigger testing for germlineBRCA1/2 mutation in patients already diagnosed with breast cancer Family history of breast, ovarian/tubal/peritoneal cancer, pancreatic, or aggressive prostate cancer Young age at diagnosis (<50 years) ...
and will simplify complex decisions by generating the best information to enable better decision-making. There is a critical unmet need for first-line treatment options for patients withBRCA-mutated metastatic castration-resistant prostate cancer, and this combination therapy is an important advancement...
Cancer is the second primary cause of mortality worldwide. The current therapeutic options for cancer treatment are surgical excision, immunotherapy, chemotherapy, and radiotherapy. Unfortunately, in case of metastases or chemoresistance, the treatment options become very limited. Despite the advances in ...
“Metastatic castration-resistant prostate cancer remains a lethal disease, with high unmet needs in terms of treatment options, particularly for patients with BRCA1/2 gene mutations,” said Elena, MD, PhD The European Medicines Agency’s Committee for Medicinal Products for Human Use (CHMP) has ...
Current Treatment Options in Oncology(2024) BRCAness of brain lesions reflects a worse outcome for patients with metastatic breast cancer Yumiko Ishizuka Yoshiya Horimoto Junichiro Watanabe Breast Cancer Research and Treatment(2024) Identification of aberrant luminal progenitors and mTORC1 as a potential ...