Among them, the BRCA genes, with the two forms ( BRCA-1 and BRCA-2 ), play a pivotal role in cancer protection and prevention. BRCA germline mutations are associated with an increased risk of developing several types of cancers, including ovarian, breast, and prostate cancers. BRCA genes ...
ImportanceHalf of all carriers of inherited cancer-predisposing variants inBRCA1andBRCA2are male, but the implications for their health are underrecognized compared to female individuals. Germline variants inBRCA1andBRCA2(also known as pathogenic or likely pathogenic variants, referred to here asBRCA1...
particularly in high-risk individuals with a family history of cancer, can play a preventive role by reducing mortality and societal impact of these genetic diseases. Recent years have witnessed the increasing
22、f brca1 and brca2 mutation carriersj.oncologist,2016,21(7):869-874.12 gallagher d j,cronin a m,milowsky m i,et al.germline brca mutation does not prevent response to taxane-based therapy for the treatment of castration-resistant prostate cancerj.bju international,2012,109(5):713-719.13...
BRCA1 and BRCA2 are tumor suppressor genes that have been linked to inherited susceptibility of breast cancer. Germline BRCA1/2 pathogenic or likely pathogenic variants (gBRCAm) are clinically relevant for treatment selection in breast cancer because the
they have cancer, in order to talk about screening for prostate cancer. And that's really gratifying. It's important for folks out there to know that we have these resources because sometimes they don't know where to go for state-of-the art cancer early detection, prevention and treatment...
https://medicalxpress.com/news/2018-03-prostate-cancer-treatment.html https://medicalxpress.com/news/2018-03-team-link-brca1-ewing-sarcoma.html http://www.onclive.com/publications/oncology-live/2018/vol-19-no-5/novel-combo-explored-for-rare-brain-tumor ...
BRCA1 and BRCA2 pathogenic variants (PVs) are associated with prostate cancer (PCa) risk, but a wide range of relative risks (RRs) has been reported. We systematically searched PubMed, Embase, MEDLINE and Cochrane Library in June 2021 for studies that es
The precision medicine and precision public health approaches to cancer treatment and prevention: a cross-comparison Like other forms of diagnostics, genetic testing comes with a retinue of costs and benefits. Significant benefits in terms of morbidity and mortality have ... SM Modell,SLR Kardia,T...
E. et al. A combined analysis of outcome following breast cancer: differences in survival based on BRCA1/BRCA2 mutation status and administration of adjuvant treatment. Breast Cancer Res. 6, R8–R17 (2004). CAS PubMed Google Scholar Quinn, J. E. et al. BRCA1 functions as a ...