A notable strength of this study was the use of unstructured NLP fields in addition to the structured data (ICD9/10 diagnosis codes) to identify the seizure outcome. In a prior study, we showed how the combi- nation of structured and unstructured data to identify adverse event outcomes is ...
Cases were defined as participants having any of the ICD-9 or ICD-10 codes for personal history of HBOC-related cancers (Additional file1: Table S1). Controls were defined as individuals without any of these ICD-9 or ICD-10 codes. We tested for association with variant-positive compared wit...
carried out association analyses by subtype for the following breast cancer characteristics: ER-positive and ER-negative, PR-positive and PR-negative, HER2-positive and HER2-negative, TN breast cancer (that is, negative for ER, PR and HER2) and non-TN (that is, tumor positive for at least ...
effectiveness of BRCA1/BRCA2 population screening (PS) in Ashkenazi Jews (AJ), for whom carrier rate is 2.5%, compared with two existing strategies: cascade testing (CT) in carrier’s relatives (≥25% carrier probability) and international family history (IFH)-based guidelines (>10% ...
However, when genetic analysis reveals a variant of uncertain significance (VUS) in the BRCA2 gene, precision medicine-based decisions become complex. VUS are genetic changes with unknown pathological impact. Current statistics indicate that between 10–20% of BRCA sequencing results are VUS, and...
Therefore, the aim of the present study was to assess the secretory function of salivary glands, selected salivary biomarkers of redox balance, and oxidative damage to proteins and lipids in subjects with breast cancer as compared to patients without breast cancer, positive or not positive for ...