Dennis J, Krewski D, Cote FS, Fafard E, Little J, Ghadirian P. Breast cancer risk in relation to alcohol consumption and BRCA gene mutations--a case-only study of gene-environment interaction. Breast J 2011;17(5):477-84.Dennis, J., Krewski, D., Cote, F.-S., Fafard, E., ...
Then, using cancer registry data collected as part of the UK Biobank study, the researchers calculated a person's risk of developing breast cancer if they had a BRCA gene mutation—both with and without a known family history of breast cancer. The investigators found that while all participants...
FDA原文如下: The U.S. Food and Drug Administration today authorized the Personal Genome Service Genetic Health Risk (GHR) Report for BRCA1/BRCA2 (Selected Variants). It is the first direct-to-consumer (DTC) test to report on three specific BRCA1/BRCA2 breast cancer gene mutations that are...
乳腺癌易感基因(breast cancer gene 1,BRCA1)和乳腺癌易感基因2(breast cancer gene 2,BRCA2)在乳腺癌发病、预防、治疗及预后方面扮演重要角色。《肿瘤瞭望》邀请乳腺癌领域大咖、上海瑞金医院李亚芬教授、上海长征医院秦文星教授和复旦大学附属华山医院汪洁教授...
5. Kurian AW, Sigal BM, Plevritis SK. Survival analysis of cancer risk reduction strategies for BRCA1/2 mutation carriers. J Clin Oncol 2010; 28: 222-231. 6. King MC, Wieand S, Hale K, et al. Tamoxifen and breast cancer incidence among women with inherited ...
Breast Cancer Risk Among Male BRCA1 and BRCA2 Mutation Carriers. Men who carry germline mutations in the BRCA2 gene have a higher risk of developing breast carcinoma than men in the general population. Men who carry germ... YC Tai,Domchek,Susan,... - 《Jnci Journal of the National Cance...
Women who carry a germ line mutation in either the BRCA1 or BRCA2 gene have a higher lifetime risk of developing breast and ovarian cancers, often at young ages. Moreover, women with BRCA-associated breast cancer develop second contralateral breast cancers (CBCs) and ovarian cancers at higher...
Knowing my #momgenes means I know I’m at risk for other cancers; it means my kids have a 50% chance of inheriting the gene; it means it may have been too late to prevent cancer in me, but it’s not too late to prevent cancer inthem. ...
乳腺癌易感基因(breast cancer susceptibility gene)BRCA包括BRCA1和BRCA2,是重要的抑癌基因,其编码产物参与DNA损伤中的同源重组修复,致病性BRCA1/2基因突变会导致同源重组缺陷(HRD),使基因组不稳定性显著增加[3]。 了解BRCA基因突变状态,有助于做好高风险人群的遗传咨询管理,包括制定筛查方案、评估家属遗传风险等。
Breast cancer survivors who carry the BRCA1 or BRCA2 genetic mutation are at high risk for developing contralateral breast cancer — a new primary tumor in the other breast — and certain women within this group of carriers are at an even greater risk ba