Breast cancer is rare in men, and family history of the disease is a risk factor. The recently discovered BRCA2 gene on chromosome 13q is thought to account for some families with increased risk of breast cancer
Aberrations of DNA repair pathways in prostate cancer: a cornerstone of precision oncology. Expert Opin Ther Targets. 2021;25:329–33. Article PubMed Google Scholar Pritchard CC, Mateo J, Walsh MF, De Sarkar N, Abida W, Beltran H, et al. Inherited DNA-repair gene mutations in men with...
[Abstract]Germline mutations inBRCAgenes (includingBRCA1/2) are the major risk factors for hereditary tumors including breast and ovarian cancer. Population basedBRCAgene screening, particularly in high-risk individuals with a ...
The meaning of BRCA is either of two tumor suppressor genes that in mutated form tend to be associated with an increased risk of certain cancers and especially breast and ovarian cancers —often used before another noun. How to use BRCA in a sentence.
Men with BRCA2 mutations located in the central region of the gene (c.2831–c.6401; ovarian cancer cluster region [OCCR], wide definition [2], [22]; see Supplementary material online) had a significantly lower risk of PCa than men with mutations outside this region (HR 0.37, 95% CI ...
[Abstract]Germline mutations inBRCAgenes (includingBRCA1/2) are the major risk factors for hereditary tumors including breast and ovarian cancer. Population basedBRCAgene screening, particularly in high-risk individuals with a family history of cancer, can play a preventive role by reducing mortality...
Two percent of men with early-onset prostate cancer harbor germline mutations in the BRCA2 gene[J]. Am J Hum Genet, 2003,72:1-12. DOI: 10.1086/345310 . 返回引文位置Google Scholar 百度学术 万方数据 [18] Kote-Jarai Z , Leongamornlert D , Saunders E ,et al. BRCA2 is a moderate ...
"These data will help to optimize medical care in male BRCA1 and BRCA2 PV carriers," Dr. Ottini said. "In particular, screening and surveillance programs in men with BRCA1 and BRCA2 PVs should be tailored in light of these gene-specific cancer phenotype differences." ...
18、-jarai z,leongamornlert d,saunders e,et al.brca2 is a moderate penetrance gene contributing to young-onset prostate cancer:implications for genetic testing in prostate cancer patientsj.british journal of cancer,2011,105(8):1230-1234.6 agalliu i,gern r,leanza s,et al.associations of hi...
Specifically, this paper does not include pre- dictive BRCA gene testing, which describes the use of a BRCA test in an asymptomatic person to predict future risk of disease, where a variant within a BRCA gene is already known within the family, and the patient's DNA is tested for that ...