The median age of childbearing in the US is age 28, therefore many BRCA mutation carriers will be pregnant or breastfeeding during the time when intensive screening is most important to manage their increased breast cancer risk. Despite this critical overlap, there is little evidence to guide ...
[4]Lang G T, Shi J X, Hu X, et al. The spectrum of BRCA mutations and characteristics of BRCA‐associated breast cancers in China: Screening of 2,991 patients and 1,043 controls by next‐generation sequencing[J]...
[4]Lang G T, Shi J X, Hu X, et al. The spectrum of BRCA mutations and characteristics of BRCA‐associated breast cancers in China: Screening of 2,991 patients and 1,043 controls by next‐generation sequencing[J]. International Journal of Cancer, 2017, 141(1): 129-142. [5]Sun J,...
[8] Kriege M, Brekelmans CT, Boetes C, et al. Efficacy of MRI and mammography for breast-cancer screening in women with a familial or genetic predisposition. N Engl J Med. 2004;351(5):427-437. doi:10.1056/NEJMoa031759 [9] Domchek SM, Friebel TM, Neuhausen SL, et al. Mortality aft...
[8] Kriege M, Brekelmans CT, Boetes C, et al. Efficacy of MRI and mammography for breast-cancer screening in women with a familial or genetic predisposition. N Engl J Med. 2004;351(5):427-437. doi:10.1056/NEJMoa031759 [9] Domchek SM, Friebel TM, Neuhausen SL, et al. Morta...
[8] Kriege M, Brekelmans CT, Boetes C, et al. Efficacy of MRI and mammography for breast-cancer screening in women with a familial or genetic predisposition. N Engl J Med. 2004;351(5):427-437. doi:10.1056/NEJMoa031759 [9] Domchek SM,...
[2] Li M, et al. Breast cancer screening and early diagnosis in China: a systematic review and meta-analysis on 10.72 million women. BMC Womens Health. 2024 Feb 7;24(1):97. [3] Lei H et al. Overview on population screening for carriers with germline BRCA mutation in China. Front ...
[2]Li M, et al. Breast cancer screening and early diagnosis in China: a systematic review and meta-analysis on 10.72 million women. BMC Womens Health. 2024 Feb 7;24(1):97. [3]Lei H et al. Overview on population screening for carriers with germline BRCA mutation in China. Front Oncol...
[8] Kriege M, Brekelmans CT, Boetes C, et al. Efficacy of MRI and mammography for breast-cancer screening in women with a familial or genetic predisposition. N Engl J Med. 2004;351(5):427-437. doi:10.1056/NEJMoa031759 [9] Domchek SM, Friebel TM, Neuhausen SL, et al. Mortality aft...
做了这么多的铺垫,终于到了我们的“正餐”——BRCA基因,BRCA基因是Breast Cancer Gene的简称,中文意为乳腺癌基因。 而在浩如烟海的人类基因之中,其发现人玛丽-克莱尔·金(Mary-ClaireKing)于1990年首次定位到了在第17号染色体上的BRCA1基因,不久之后人们又发现了位于13号染色体上的BRCA2基因。