奥拉帕利是一种口服PARP抑制剂(PARPi),通常用于治疗携带BRCA突变肿瘤患者,尤其是乳腺癌和卵巢癌患者。程序性细胞死亡受体-1(PD-1)抑制剂通过破坏肿瘤免疫微环境中受体与配体之间的相互作用,使T细胞能够识别和攻击癌细胞。其彻底改变了肺癌和许多其他癌症的治疗方法。本文报告了一例携带BRCA2突变的晚期肺鳞癌患者,其...
[2] Wenfeng Fang, Xiuyu Cai, Huaqiang Zhou, Yinguang Wang, Yaxiong Zhang, Shaodong Hong, Yang Shao, and Li Zhang. BRCA1/2 germline mutations and response to PARP inhibitor treatment in lung cancer. Journal of Cl...
生物通推荐原文摘要: Rare variants of large effect in BRCA2 and CHEK2 affect risk of lung cancer Abstract:We conducted imputation to the 1000 Genomes Project of four genome-wide association studies of lung cancer in populations of European ancestry (11,348 cases and 15,861 controls) and genotyp...
germline BRCA1 mutation and HRD in a lung cancer patient: Molecular considerations and treatment decision-making. Tumori. 2024 Jun 13:3008916241257754. doi: 10.1177/03008916241257754. Epub ahead of print. PMID
Rare variants of large effect in BRCA2 and CHEK2 affect risk of lung cancer. Nat Genet 2014;46:736-41.Wang Y, McKay JD, Rafnar T et al. Rare variants of large effect in BRCA2 and CHEK2 affect risk of lung cancer. Nat Genet 2014; 46: 736-741....
对于肺癌,最好的办法就是早发现早治疗。及时发现“坏基因”,让自己和家人远离肺癌。 癌度,陪您走好防癌抗癌的每一步! 参考文献: Andrew S. Rifkin, et al., Association of reported candidate monogenic genes with lung cancer risk, Clinical Lung Cancer (2023)...
DATSENKO P V, GERASIMOV V A, BELIKOVA A A. Shortterm survival prediction scale in patients with metastatic brain disease caused by lung and breast cancer[J]. Zh Vopr Neirokhir Im N N Burdenko, 2020, 84(4): 26-35...
http://www.onclive.com/conference-coverage/mlcc-2018/brahmer-highlights-latest-on-immunotherapy-and-other-lung-cancer-advances 声明: 本公众号内容仅作交流参考,不作为诊断及医疗依据,仅依照本文而做出的行为造成的一切后果,由行为人自行承担责任。专业医学问题请咨询专业人士或专业医疗机构。
Nechushtan H. Clinical Characteristics, Response to Platinum-Based Chemotherapy and Poly (Adenosine Phosphate-Ribose) Polymerase Inhibitors in Advanced Lung Cancer Patients Harboring BRCA Mutations. Cancers (Basel). 2023 Sep 26;15(19):4733. doi: 10.3390/cancers15194733. PMID: 37835426; PMCID: PMC105...
BRCA2 and monocytes can synergistically inhibit lung cancer and regulate the expression of ATM signaling pathway molecules.［Key words ］ RNAi technology ；BRCA2 gene ；Peripheral blood mononuclear cells ；Lung cancer 肺癌是高发恶性肿瘤。在我国，每年新增肺癌患者约73万例，病死患者达到61万［1］。手术...