[7] Yao L, Sun J, Hu L, et al. Ovarian cancer risk of Chinese women with BRCA1/2 germline pathogenic variants[J]. J Hum Genet, 2022, 67(11):639-642. doi: 10.1038/s10038-022-01065-6 [8] Pierce LJ, ...
review provides a comprehensive analysis of studies conducted between 1994 and June 2024, focusing on the link between specific mutations in the breast cancer susceptibility gene 1 (BRCA1) and breast cancer susceptibility gene 2 (BRCA2) and the associated risks of both breast and ovarian cancers....
[1] Matan LS, Perri T, Kogan L, et al. Ovarian cancer risk management in BRCA-mutation carriers: A comparison of six international and national guidelines[J]. Eur J Obstet Gynecol Reprod Biol, 2022,278:166-171. [2] Daly MB, Pal T, Berry MP, et al. Genetic/Familial High-Risk Asses...
2. Gayther, S.A., et al., The contribution of germline BRCA1 and BRCA2 mutations to familial ovarian cancer: no evidence for other ovarian cancer-susceptibility genes. Am J Hum Genet, 1999. 65(4): p. 1021-9. 3. Ramus, S.J., et al., Contribution of BRCA1 and BRCA2 mutations ...
and ovarian cancer based on mutation type, function, and nucleotide position. We also estimated RHR, the ratio of breast vs ovarian cancer hazard ratios. A value of RHR greater than 1 indicated elevated breast cancer risk; a value of RHR less than 1 indicated elevated ovarian cancer risk. ...
[2]Kuchenbaecker KB, Hopper JL, Barnes DR, et al. Risks of Breast, Ovarian, and Contralateral Breast Cancer for BRCA1 and BRCA2 Mutation Carriers. JAMA. 2017;317(23):2402-2416. doi:10.1001/jama.2017.7112 [3]Oh M, Alkhushaym N, Fallatah S, et al. The association of BRCA1 and BRCA...
[2]Kuchenbaecker KB, Hopper JL, Barnes DR, et al. Risks of Breast, Ovarian, and Contralateral Breast Cancer for BRCA1 and BRCA2 Mutation Carriers. JAMA. 2017;317(23):2402-2416. doi:10.1001/jama.2017.7112 [3]Oh M, Alkhushaym N, Fallatah S, et al. The association of BRCA1 and BRCA...
[1]Armstrong K, Weiner J, Weber B, Asch DA. Early adoption of BRCA1/2 testing: who and why. Genet Med. 2003;5(2):92-98. doi:10.1097/01.GIM.0000056829.76915.2A [2]Kuchenbaecker KB, Hopper JL, Barnes DR, et al. Risks of Breast, Ovarian, and Contralateral Breast Cancer for BRCA1...
Purpose: Several studies to date have reported ovarian cancer risk due to inherited BRCA1 and BRCA2 mutations using familial data or population-based series of probands. Familial aggregation associated with both of these methods may result in a substantial ascertainment bias. To address this, we ...
Variation of breast cancer risk among BRCA1/2 carriers. JAMA. 2008;299(2):194-201.ArticlePubMedGoogle ScholarCrossref 5. Brohet RM, Velthuizen ME, Hogervorst FB, et al; HEBON Resource. Breast and ovarian cancer risks in a large series of clinically ascertained families with a high ...