Genetic counselling and genetic testing will be critically evaluated and the implications for clinical practice, the individual and society as a whole will be discussed.doi:10.1054/ejon.2002.0200Claire E BalmerElsevier LtdEuropean Journal of Oncology NursingBalmer, C.E. 2002. BRCA1 and BRCA2 ...
1. Liming Su, et al. Contralateral breast cancer risk in BRCA1 and BRCA2 mutation carriers in a large cohort of unselected Chinese breast cancer patients. Int. J. Cancer, 2020, 146: 3335-3342. 2. Yadav S,Hu C,Hart SN,et al.Evalu...
这项研究发现,携带BRCA1或BRCA2基因突变的女性,50-75岁时患所有类型癌症的风险高达67%-77%;而采取预防性措施,将显著降低风险。 图片来源:123RF 研究者对2211名携带了BRCA1或BRCA2基因突变的女性参与者进行了随访研究。其中,1470名携带了BRCA1基因突变,平均年龄是50.2岁;741名携带了BRCA2基因突变,平均年龄是52.4岁...
In the ten years since the discovery of BRCA1 and BRCA2, genetic testing for breast and ovarian cancer susceptibility has become integrated into the practice of clinical oncology. Attempts to identify a third breast cancer susceptibility locus (BRCA3) have so far been unsuccessful. This is probab...
2. Liede A, Narod S A:Hereditary breast and ovarian cancer in Asia: genetic epidemiology of BRCA1 and BRCA2. Hum Mutat 2002; 20: 413-424. 3. US Preventive Services Task Force, Owens DK, Davidson KW, et al. Risk assessment, genetic counseling, and genetic test...
ARTICLE Timing of BRCA1/BRCA2 genetic testing in women with ovarian cancer Molly S. Daniels, MS1, Diana L. Urbauer, MS2, Jennifer L. Stanley, BS1, Kristin G. Johnson, BSN3, and Karen H. Lu, MD1 Purpose: To determine when, in reference to the course of their treatment, women with...
“Pathway’s mission is to ensure that people in need receive genetic testing regardless of their economic or insurance status,” said Jim Plante,Pathway Genomics’ founder and CEO. “Offering the industry’s bestBRCAgenetic test and making it accessible to a wide range of people is a vital ...
METHODS: This study was combined with quantitative and qualitative designs. First, we performed a quantitative investigation using FACT-B (Chinese version) and Irritability, Depression and Anxiety scale (IDA) to assess the QOL and PS in breast cancer patients who received BRCA1/2 genetic testing....
1.家族遗传性乳腺癌诊疗进展 1.1 国内乳腺癌易感基因研究数据逐步积累 2021年两项大样本病例对照研究分析了欧美人群总计超过近18万例的乳腺癌易感基因突变数据显示,BRCA1和BRCA2的致病胚系突变增加至少5倍以上的乳腺癌发病风险,TP53和PALB2的致病突变增加3-5倍的乳腺癌发病风险;而ATM、CHEK2、BARD1、RAD51C、RAD...
1.Risk Assessment, Genetic Counseling, and Genetic Testing for BRCA-Related Cancer in Women. JAMA,doi:10.1001/jama.2019.8430 2. New Guidelines Expand BRCA Screening Guidelines. 3.USPSTF Formalizes Slightly Expanded BRCA Screening Recommendations. ...