Branched-chain amino acids (BCAAs) are essential amino acids which have critical roles in protein synthesis and energy metabolism in the body. In the heart, there is a strong correlation between impaired BCAA oxidation and contractile dysfunction in heart failure. Plasma and myocardial levels of ...
et al. Branched chain amino acids are novel biomarkers for discrimination of metabolic wellness. Metabolism 62, 961–969 (2013). CAS PubMed PubMed Central Google Scholar Huang, Y., Zhou, M., Sun, H. & Wang, Y. Branched-chain amino acid metabolism in heart disease: an epiphenomenon or...
Branched-Chain Amino MetabolismThe branched-chain amino acids (BCAAs) leucine, isoleucine, and valine are known to enhance protein synthesis and improve energy homeostasis. While BCAAs cannot be synthesized endogenously, they are subjected to transamination by the branched-chain aminotransferases (BCATs...
Nature Metabolism1,532–545 (2019)Cite this article 14kAccesses 220Citations 536Altmetric Metrics Abstract Elevated branched-chain amino acids (BCAAs) are associated with obesity and insulin resistance. How long-term dietary BCAAs impact late-life health and lifespan is unknown. Here, we show tha...
Branched-chain amino acid (BCAA) catabolism has been considered to have an emerging role in the pathogenesis of metabolic disturbances in obesity and type 2 diabetes (T2D). Several studies showed elevated plasma BCAA levels in humans with insulin resista
Branched-Chain Amino Acids : Metabolism , Physiological Function , and Application Potential Importance of Leucine in Treatment of Obesity and theLayman, Donald KWalker, Denise A
Since BCAAs along with aromatic amino acids are critical for production and maintenance of brain neurotransmitters, here we tested if BCAA metabolism in liver - an organ with the highest BCAA degradation activity - is impaired in AD. Methods: Eight month-old wildtype or AD transgenic mice were...
Branched-chain amino acids (BCAA) are a set of well-known biomarkers of insulin resistance and predictors ofT2DM. Although the role of BCAA in regulating metabolism is still unclear, several studies showed that the intake of rich BCAA diets prevented obesity and insulin resistance, meanwhileBCAA ...
Branched-chain amino acid (BCAA) metabolism fulfills numerous physiological roles and can be harnessed to produce valuable chemicals. However, the lack of eukaryotic biosensors specific for BCAA-derived products has limited the ability to develop high-th
Branched-chain amino acid (BCAA) catabolism and high levels of enzymes in the BCAA metabolic pathway have recently been shown to be associated with cancer growth and survival. However, the precise roles of BCAA metabolism in cancer growth and survival remain largely unclear. Here, we found that...