shows three key findings: (i) the absence of gut microbiota in GF mice resulted in decreased immobility time in the forced swimming test relative to conventionally-raised healthy control mice. (ii) From clinical sampling, the gut microbiotic compositions of MDD patients and healthy controls were ...
PubMed CentralGoogle Scholar Crane JD, Palanivel R, Mottillo EP, Bujak AL, Wang H, Ford RJ. Inhibiting peripheral serotonin synthesis reduces obesity and metabolic dysfunction by promoting brown adipose tissue thermogenesis.Nat Med2015;: 166–172. Google Scholar . The gut microbiome contributes to...
Other pathways by which the gut microbiota could influence the development and activity of brain tissue include regulation of the release of gut peptides from enteroendocrine cells,204which in turn affect gut–brain hormonal communication,205,206and, as described above, the regulation of microglia hom...