To test whether environmental factors could explain the modifying effect of sex on genetic regulation of protein expression for the identified 150 proteins with sb-pQTLs, we examined the environmental factors present in our dataset, including lifetime alcohol use, smoking, comorbid medical conditions a...
Difference between groups was determined by independent-samples t test. P-values of less than 0.05 were considered statistically significant. RESULTS General Data The body weight of 21-day groups was measured consecutively, which was illustrated in Figure 1. Though the 2 groups both gained ...
P-values were determined by Wilcoxon rank-sum test (two-sided) and adjusted by Benjamini–Hochberg procedure. FC, fold change. c, Low-dimensional UMAP embeddings of the pixel-wise lipid profiles across different brain serial sections, revealing region-specific lipid distributions across a tissue ...
12,33]. The Z chromosome was enriched with male-biased genes in both the zebra finch (351 genes) and the common whitethroat (231 genes), and in the zebra finch female-biased genes were also overrepresented on the Z chromosome (7 genes). This is in line with...
(violet boxes). The type III fixed effects test was used to determine statistical significance, and the LMS method was applied to compare between groups and time points. Box charts present the dispersion and the shape of the data distribution for the test value in the compared populations. The...
The effect was statistically significant also when expressed in terms of mean activation over predefined anatomical volume of interests (P<0.05, all regions, Student’s t-test; Figure 1c). No brain regions exhibited significant reductions of bCBV in D-Asp-treated animals. No significant ...
Significantly higher bindings of MS CSF IgG to phage Pep 3–3 (EBNA1) compared IC CSF are shown in a (p = 0.0075; Mann-Whitney nonparametric test). For phage 3–2 (EBNA2), there is no significant difference for bindings between MS and IC CSF. Phage counts (averages of duplicate ...
The intra- and inter-specific variation in each parcellated brain region was analysed and evaluated based on the Cohen’s d effect size and statistical test. We confirmed that our results are not affected by the use of the averaged brain for our reconstructions (See Extended Data Fig. 4). ...
The P-value was calculated as the proportion of simulated test statistics that are more extreme than the observed test statistic, and then corrected for multiple comparisons. The second one was constructed to examine whether the spatial pattern of structure-function coupling is correlated with the ...
For binary data (the presence or absence of post-FUS T2 changes suggestive of tissue damage at different microbubble doses) an online two-tailed two population proportion test was used34. Image processing Window level (WL) and window width (WW) of all contrast-enhanced T1-weighted images were...