and monitor RT-induced neurotoxicity in vivo and can be used as a biomarker for noninvasive evaluation of RT-induced brain injury; (b) Longitudinal changes in brain structure, especially in the temporal lobe, are dose dependent; (c) Longitudinal changes in brain structure are time dependent; (...
For instance, the MR decreases p53 levels and the ratio of pro-apoptotic to antiapoptotic Bcl-2 members in neuronal cells [48], [49]. Moreover, MR may play a more important tole than the GR in terms in the anti-apoptotic function of TUDCA [49]. 3. Pathogenesis and therapeutic targets...