Synergistically with dose-dependent anti-inflammatory properties, E2 further exerts neuroprotective activity in the brain via the modulation of other cell types such as: (i) neurons, through anti-apoptotic and neurotrophic actions; (ii) neural stem cells, by inducing their proliferation; (iii) astrog...
UABD nanomedicines, as the key components of the UABD technology, have become a major subject of interest in brain tumor therapy, and studies on the treatment of brain tumors and other diseases, such as stroke, Alzheimer's disease (AD), Parkinson's disease, and Huntington's dance syndrome,...
anterior brain, hippocampus, hypothalamus, cerebellum, brain stem, and CSF after nasal administration to mice, and the level was approximately 20 times higher than when administered intravenously (Nonaka et al.2008). These results indicate that the nasal-brain pathway could deliver substances from the...
Stem Cells 36(9):1404–1410 Article CAS PubMed PubMed Central Google Scholar Hayakawa K, Esposito E, Wang X, Terasaki Y, Liu Y, Xing C, Ji X, Lo EH (2016) Transfer of mitochondria from astrocytes to neurons after stroke. Nature 535(7613):551–555 Article CAS PubMed PubMed Central...
the person acts as if he or she is having astroke. In some patients, the symptoms may be more pronounced if the cancer is located mainly in a specific brain lobe that is usually responsible for certain body functions. For example, behavioral changes may predominate in frontal-lobe cancers wh...
a Jane Coffin Childs postdoctoral fellowship sponsored by the Simons Foundation (Castellano), US Department of Veterans Affairs (Wyss-Coray), grant AG045034 from the National Institute on Aging (Wyss-Coray), and grant NS083508 from the National Institute on Neurological Disorders and Stroke (Kirby)...
In normal or disease conditions, neurogenesis involves four general cellular events: i) proliferation of stem/progenitor cells; ii) migration of stem/progenitor cells into different areas of the central nervous system; iii) differentiation into specific neuronal cell types; iv) integration in the esta...
What do spiders and Alzheimer's disease have in common? A team of researchers may have just uncovered the answer. Researchers from have made a groundbreaking connection between brain 'waste canals' and Alzheimer's disease -- a discovery inspired by studying spider brains. Their findings offer a...
Montelukast treatment significantly enhanced pro- liferation, and this effect was specific for the old individuals (Fig. 3a). The surplus in PCNA þ cells in the old montelukast- treated animals was apparently not due to an enlargement of the neural stem cell pool, as the number of ...
Neuro-oncology is defined the study of brain and spinal cord neoplasms, many of which are (at least eventually) very dangerous and life-threatening (astrocytoma, glioma, glioblastoma multiforme, ependymoma, pontine glioma, and brain stem tumors are among the many examples of these). Among the ma...