While single-cell technologies have greatly advanced our comprehension of human brain cell types and functions, studies including large numbers of donors and multiple brain regions are needed to extend our understanding of brain cell heterogeneity. Integrating atlas-level single-cell data presents a chan...
Brainstem regions support vital bodily functions, yet their genetic architectures and involvement in common brain disorders remain understudied. Here, using imaging-genetics data from a discovery sample of 27,034 individuals, we identify 45 brainstem-associated genetic loci, including the first linked to...
2020年起至今担任南加州大学副教授。他的研究通过使用小鼠和人类类器官模型研究大脑和颅面发育、退化和疾病,并在Science Advances,CellStem Cell,Nature Communications等杂志发表数篇论文。 欢迎大家参与交流学习! - 中山大学医学院 - 排版:...
We next employed the striatal coexpression modules to decipher the striatal transcriptomic signatures from Huntington’s disease models and heterozygous null mice for 52 genes, uncovering novel functions for Prkcq and Kdm4b in oligodendrocyte differentiation and bipolar disorder-associated Trank1 in ...
An ever-increasing list of protein, such as insulin, leptin, and lipoproteins, essential for brain functions has been proposed to be transported using the RMT [[22], [23], [24], [25]]. One of the most studied RMT receptors is the transferrin receptor (TfR) which mediates the delivery ...
including the maintenance of stem cells, specification of cell fate, differentiation, and proliferation [71]. Surprisingly, however, theInsulin-related peptide (Ilp2), a component of the insulin signalling pathway, was downregulated in the tumor condition. Overexpression of Ilp2 alters growth control...
Validated putative miRNAs. (A) Sequences for both mature miRNA and predicted pre-miRNA. Copy number refers to the occurrences of the mature sequences in the E15.5 whole brain small RNA sequencing analysis. (B) RNAfold prediction of the stemloop hairpin structure. The colours in the vertical ...
The diencephalon is known for relaying the auditory and optic signals (thalamus) between the brain stem and the cerebrum, maintaining sleep cycles (pineal gland) and endocrine and autonomic functions (hypothalamus). The pituitary gland is involved in the secretion of the thyroid-stimulating hormone ...
(CNS). Other not-negligible functions are represented by basic cellular activities also referred to as “housekeeping”: macromolecule and organelle turnover and axonal transportation, for example [1]. Despite this great demand, the brain does not have a sufficient reservoir of energy: only a ...
These two regions connect to the hypothalamus, which plays a role in basic functions like sleep, appetite and libido, and to three other important regions of the brain: the amygdala, which evaluates emotional salience; the hippocampus, which is concerned with memory; and the prefrontal cortex, ...