my loved one had a brain stem stroke five days ago. He received tpa meds after going to er. The first two days he could speak with slurred speech, could move his limbs. on day four, he had a nose bleed and they had to put him on respirator. he is now sedated and on temporary ...
A recent report35 demonstrates efficient in vivo prime editing in enriched degenerating retinitis pigmentosa mouse retinas with dual-AAV delivery of PE-SpRY, but this system may not be applicable to uses that do not confer a survival advantage among edited cells. Adenoviral transduction has yielded ...
Traumatic brain injury (TBI) can result in long-lasting changes in hippocampal function. The changes induced by TBI on the hippocampus contribute to cognitive deficits. The adult hippocampus harbors neural stem cells (NSCs) that generate neurons (neurogenesis), and astrocytes (astrogliogenesis). Whil...
Gap junctions are found throughout the mammalian brain and are important regulators of stem cell behavior, controlling self-renewal, survival, and aging (Kar et al., 2012, Wong et al., 2008). Here we show that gap junction proteins play a key role in the nutrient-dependent reactivation of...
Glioblastoma multiforme (GBM) is the most common and aggressive cancer of the central nervous system, with an age-adjusted incidence rate of 3.2 per 100,000 individuals [1] and a median survival time of 15 months [2]. The standard of care consists of surgical resection followed by adjuvant...
Cell survival rate was measured using MTS assay. Data was normalized to cells treated as above under normoxic conditions. Cell Adhesion Assays Brain endothelial cells±pre-incubation with α5β1 function blocking antibody were added to wells coated with 1% BSA or 10 μg/ml DV, followed by ...
Experiment 3 Although warfarin did not significantly increase HEM volume (Fig. 7a; p = 0.1418), it tripled the time for the tail bleed to clot (Fig. 7b; p < 0.001). Fig. 4 Percent of sampled tissue with greater than 25% change (arbitrary threshold likely to denote biological ...
In response to this “everyday violence,” Scheper-Hughes argues that shantytown mothers practice emotional distancing from their children during the first year of life when their survival is most uncertain, and they do not grieve or mourn the death of their children in “natural” or “...
Alternatively, blood tests for brain injury may not be as obviously and tangibly convincing for clinicians who may still feel compelled to perform a CT of the head to rule out a brain bleed. What is the new hope presented with the recent approval of Abbott’s Alinity i TBI test? The new...