2, such as normal brain aging3, neurodegenerative disorders such as Alzheimer’s disease (AD)4, and brain cancer5. Based on magnetic resonance imaging (MRI), AI-derived measures of the human brain age6,7,8have emerged as a valuable biomarker for evaluating ...
Huntington’s disease (HD) is a progressively debilitating neurodegenerative disease exhibiting autosomal-dominant inheritance. It is caused by an uns
Comprehensive studies using resting state fMRI and a graph theory approach have shown that the statistical properties of endogenous fluctuations are modulated in Alzheimer’s disease47, Parkinson’s disease48, autism spectrum disorders49 and multiple sclerosis50. In this study, in the allodynia mouse ...
1990-2017 Global Disparities in Parkinson Disease Guidelines for Reporting Outcomes in Trial Protocols: The SPIRIT-Outcomes 2022 Extension Mass Violence and the Complex Spectrum of Mental Illness and Mental Functioning Neuropsychiatry Sequelae of COVID-19 A New Framework for Dementia Nomenclature Organizatio...
A longitudinal fixel-based analysis of white matter alterations in patients with Parkinson's disease NeuroImage: Clinical, Volume 24, 2019, Article 102098 Yi-Ai Rau,…, Jiun-Jie Wang View PDF Development of white matter fibre density and morphology over childhood: A longitudinal fixel-based analys...
Conway et al., “Acceleration of oligomerization, not fibrillization, is a shared property of both α-synuclein mutations linked to early-onset Parkinson's disease: implications for pathogenesis and therapy,” Proceedings of the National Academy of Sciences, 2000, pp. 571-576, vol. 97, No. 2...
Changes in DAT expression are associated with neurological and psychiatric disorders such as ADHD, autism, and Parkinson's disease (PD) [93]. In line with our findings, previous studies in PD patients (who were characterized by an altered striatal DAT expression due to nigrostriatal dopaminergic ...
The specific mechanisms underlying the therapeutic effects of DBS in SUDs treatment have not yet been fully elucidated. However, from the perspective of leveraging the progress in DBS for other neurologic conditions, such as major depressive disorder and Parkinson’s disease, DBS is believed to exert...
(methamphetamine) users revealed higher MD in regions of the dopaminergic system.37 Further, an intervention study of Parkinson's disease revealed that adminis- tration of the dopamine agonist L-dopa led to increased MD in regions of the dopaminergic system.14 Therefore, a greater amount of VGP ...
activators of HDAC1 yielded exifone as an HDAC activator and a strong candidate for such a therapeutic strategy (Supplementary Fig.9a)52. Exifone has also been shown to have pro-cognitive effects in animal models and in patients with Alzheimer’s-type dementia and Parkinson’s disease53,54,55...