The pathways to addiction can be difficult to understand, because substance abuse, as a result of the intense burst of pleasure it brings, rapidly rewires the circuitry of the brain to become highly efficient at drug wanting and seeking. At first glance, the fact that addiction shifts the way...
Enhanced midbrain response at 6-month follow-up in cocaine addiction, association with reduced drug-related choice. Addict Biol, 17, 1013-1025.Moeller SJ, Tomasi D, Woicik PA, Maloney T, Alia-Klein N, Honorio J, et al. Enhanced midbrain response at 6-month follow-up in cocaine ad- ...
GDNF has been shown to protect and promote recovery of brain dopaminergic neurons in animal models of Parkinson's disease. As brain dopaminergic pathways are important for perceiving drug reward, and as they undergo plastic changes during chronic drug use, interactions between GDNF and responses to ...
Human neuroscience documents restoration of functioning after abstinence [40, 41] and reveals predictors of clinical success [42]. If anything, this evidence suggests a need to increase efforts devoted to neuroscientific research on addiction recovery [40, 43]. Lessons from genetics For alcohol ...
mediators in drug addiction3. Therefore, because of dopamine’s role in the NAc and mPFC after drug exposure and ethanol’s ability to directly modulate VTA dopamine activity, we sought to determine how VTA neurons that project to the NAc and mPFC are altered after the alcohol drinking ...
Slow Recovery Fortunately for the patient, he slowly recovered after 26 days in the hospital, followed by a stay in a skilled nursing facility to help regain his speech and function. He is now home with his family in the Seattle area and back to work. To this day, he has no memory of...
"When people treat drug addicts, they need to know that during withdrawal, people in recovery may experience cognitive consequences," said Habibeh Khoshbouei, an associate professor of neuroscience and psychiatry in the UF College of Medicine. "Theirbrain chemistryhas changed." ...
Interestingly, beneficial effects of DCS were reported in a range of animal models of human diseases as well as in several clinical indications thought to involve disruptions inNMDAR function, such as drug addiction, post-traumatic stress disorder, Parkinson's disease, aging and psychiatric disorders...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is associated with short- and long-term neurological complications. The variety of symptoms makes it difficult to unravel molecular mechanisms underlying neurological sequalae after c
Frontiers in Addiction Research: Celebrating the 35th Anniversary of the National Institute on Drug Abuse N.D.Volkow, ...F.Telang, inNeuropharmacology, 2009 Brain imagingtechniques have contributed greatly to this new understanding. They have allowed us to measure neurochemical and metabolic processes...