S2). In both cases, dark avoidance behavior was significantly attenuated compared to respective sibling controls (Fig. 1F’-F”), indicating that, different from the fast-timescale defensive response, the choice to avoid dark in an 8-minute timescale requires CRF neuropeptide signaling....
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tion template or hemodynamic response function (Ferenczi We then mapped the voxels that significantly contributed et al, 2016; Leite et al, 2002; Monti, 2011) (Supplementary to the PC representing the stimulation effect back to a T2- Figure S2E), optogenetic stimulation of THVTA neurons ...
Several neuropsychiatric conditions, such as addiction and schizophrenia, may arise in part from dysregulated activity of ventral tegmental area dopaminergic (THVTA) neurons, as well as from more global maladaptation in neurocircuit function. However, wh
Holtman IR, Raj DD, Miller JA, Schaafsma W, Yin Z, Brouwer N, Wes PD, Möller T, Orre M, Kamphuis W, Hol EM, Boddeke EWGM, Eggen BJL (2015) Induction of a common microglia gene expression signature by aging and neurodegenerative conditions: a co-expression meta-analysis. Acta Neur...
Supplementary Information Additional file 1: Table S1. Additional file 2: Table S2. Additional file 3: Table S3. Additional file 4: Figure S1–S21. Rights and permissions Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharin...
response desensitization has long lurked under the dual-process theory as the putative "generalization of habituation" [75] or "transfer of habituation" [76,77] (see Sect. 2.1.2), sometimes also called "extrinsic habituation" RFeigsuporens2e desensitization and phantom sensation Response desensit...
Brain inflammation plays a key role in neurological disease. Although much research has been conducted investigating inflammatory events in animal models, potential differences in human brain versus rodent models makes it imperative that we also study th
Shen H, Moussawi K, Zhou W, Toda S, Kalivas PW. Heroin relapse requires long-term potentiation-like plasticity mediated by NMDA2b-containing receptors. Proc Natl Acad Sci USA. 2011;108:19407–12. CAS PubMed PubMed Central Google Scholar Shen HW, Scofield MD, Boger H, Hensley M, Kali...
Shen H, Moussawi K, Zhou W, Toda S, Kalivas PW. Heroin relapse requires long-term potentiation-like plasticity mediated by NMDA2b-containing receptors. Proc Natl Acad Sci USA. 2011;108:19407–12. CASPubMedPubMed CentralGoogle Scholar