a Representative fluorescent images (from 2 replicates) of basal MLVs (labeled with LYVE-1, green and PROX-1, yellow) in each group. Scale bar: 20 μm. b Quantitative analysis (from 2 replicates) of the diameter of MLVs in each group. P(Sham vs IVH+PS)<0.001; P(IVH vs IVH+PS)<...
We treated control and C9 hiPSCs and ALI-COs with the TOP1i in the presence and absence of a specific ATM inhibitor (ATMi; AZD2553) and immunolabeled cells for γ-H2AX, which is an established marker for DNA damage signaling43 (Extended Data Fig. 5b). In contrast to astroglia, C9 AL...
"There's part of the brain that has to do primarily with vision and other parts that have to do primarily with sound. Now, can we look in the vision section and say, Is there a special part of the brain that detects red objects and another that detects green objects? Or does the sa...
Regardless of how love is categorized, labeled, or defined, the experience of love, regardless of type is unique to very. Love is universally acknowledge, felt and expressed. The great equalizer so to speak; given the uncontrollable impact it has on the brain it can make the most eloquent s...
Annotated clusters of significant pathway similarities and high weights are labeled (5), along with the genes enriched within that group beyond the rest of the network. Each node is colored according to the enrichment score of that term, from PC1 (yellow) to PC15 (dark purple) according to...
However, in a traditional folder system, these rich associations are buried. You might have a folder labeled “Travel,” but it won’t naturally connect to the “Books” folder or the “Recipes” folder where you stored that croissant recipe. It’s like having a beautiful dress hidden deep...
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Samples were vacuum dried and labeled with iTRAQ4 (Sciex Inc.) or TMT10 (Thermo Scientific) kits. Each iTRAQ 4-plex consisted of 2 replicate experimental IPs using an antibody against the protein of interest (i.e., an index protein), and 2 replicate control IPs using a control IgG ...
a Scheme of the experimental design with retroAAV injected in the lesion area and timeline of the two-photon in vivo imaging. b Confocal images of retrogradely labeled callosal neurons in the cortex (Green: retroAAV-EGFP; red: NT435). Insets are four times magnified (top raw overlay; mid...
aUniform manifold approximation and projection (UMAP) representation of total CD45+ brain cell populations identified by mass cytometry with the colors and numbers corresponding to cell types delineated by FlowSOM-guided clustering, including distinct microglial, border macrophage (BAMs), B cell (B),...