MRI data was pre-processed with Freesurfer 6.0.059,60 to estimate cortical thickness, surface area and subcortical volumes. Data was processed on King’s College London HPC infrastructure Rosalind (https://rosalind.kcl.ac.uk), with the standard recon-all procedure, consisting of motion correction...
Kinetic parameters were estimated using: (1) MRI-derived brain volumes, (2) stable isotope labeling kinetics (SILK) of amyloid-β peptide (Aβ), and (3) lumbar CSF Aβ concentration during SILK. Here we show that changes in blood-brain barrier transport and/or proteolysis were largely ...
34. To determine the impact of ATV:TREM2 on this function, we administered antibodies in vivo and then evaluated microglial uptake of myelin or Aβ ex vivo. WT;human TREM2 tg;TfRmu/humice were IV dosed with isotype control, ATV:TREM2 or anti-TREM2; brain microglia were harvested 2...
prediction. Resting-state functional MRI data were preprocessed identically in all three studies. The applied, nipype-based workflow is depicted on Supplementary Fig.1. It utilised third-party neuroimaging software, code adapted from the software tools C-PAC53and niworkflows54, and in-house python ...
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