What makes them better or worse? Depending upon the circumstances, the patient may not have insight or may not remember the symptoms or complaints, and it may be up to a family member, caregiver, or friend to supply the appropriate information. Medical history and physical exams Reviewing the ...
A central question in systems neuroscience is how brain-network architecture supports a wide repertoire of human behavior across the lifespan. Childhood is a period of rapid neural development and behavioral changes across cognition, personality, and mental health1,2,3. Consequently, there is particul...
Lifespan brain trajectories are nonlinear and differ between regions, as illustrated in Fig. 1 for volumes of cerebral white matter, cortex, and hippocampus for 4352 observations of 2017 healthy participants from the Center for Lifespan Changes in Brain and Cognition longitudinal studies (Fjell, Id...
Functional connectivity patterns in the human brain, like the friction ridges of a fingerprint, can uniquely identify individuals. Does this “brain fingerprint” remain distinct even during Alzheimer’s disease (AD)? Using fMRI data from healthy and pathologically ageing subjects, we find that indivi...
2014). These reports suggest that differences in network function between patients with and without complaints may be strongly associated with non-injury related factors, such as pre-injury mental problems, personality factors and current life stress. We deem it plausible that network findings after ...
Long COVID patients reported persistent cognitive symptoms such as memory problems and brain fog, with higher levels of fatigue and reduced quality of life compared to controls. Despite subjective cognitive complaints, cognitive tests did not reveal significant differences between groups, except for the...
Secondary outcomes include patient-reported measures of pain intensity, depression, anxiety, sleep disturbance, and health-related quality of life. Discussion The R2D2 trial will be the largest and longest prospective randomized trial testing the impact of an anticholinergic-specific deprescribing ...
Q3. Do your memory or concentration problems affect your everyday life? Q4. During the past month, have you often been bothered by feeling down, depressed or hopeless? Q5. During the past month, have you often been bothered by little interest or pleasure in doing things? The CDT [23] ...
Although most subjects did not present significant impaired scores compared with the normative data, we speculate that the low average performance affecting different domains may result in a negative impact in everyday life, especially in individuals with high levels of education and cognitive demands....
impacting brain health7and quality of life8. Standardized tasks of social cognition are increasingly used in research and clinical contexts to assess the performance of patients with age-related conditions such as subjective cognitive complaints (SCC), mild cognitive impairment (MCI) and dementia, in...