Simultaneous hypersecretion of CSF and of brain interstitial fluid causes idiopathic intracranial hypertension. Med Hypotheses 2003;61:529e32.Iencean, S.M., 2003. Simultaneous hypersecretion of CSF and of brain interstitial fluid causes idiopathic intracranial hypertension. Medical Hypotheses. 61: 529-...
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CSF from the subarachnoid space moves rapidly into the brain along paravascular routes surrounding penetrating cerebral arteries, exchanging with brain interstitial fluid (ISF) and facilitating the clearance of interstitial solutes, such as amyloid beta, in a pathway that we have termed the "glymphatic...
et al. The sleep-wake cycle regulates brain interstitial fluid tau in mice and CSF tau in humans. Science 363, 880–884 (2019). Lucey, B. P. et al. Reduced non–rapid eye movement sleep is associated with tau pathology in early Alzheimer’s disease. Sci. Transl. Med. 11, eaau6550...
24. Holth JK, Fritschi SK, Wang C, Pedersen NP, Cirrito JR, Mahan TE, Finn MB, Manis M, Geerling JC, Fuller PM, Lucey BP, Holtzman DM. The sleep-wake cycle regulates brain interstitial fluid tau in mice and CSF tau in humans. Science, 2019. ...
The discussion below attempts to relate Aβ-containing cerebral spinal fluid (CSF) and interstitial fluid (ISF) brain fluid movements10, 11 to the initial causes of these amyloid diseases. Such fluid movements generate different critical types of shear energy that the author suggests have been ...
The interstitial fluid of the brain is believed to be similar to the CSF, mostly water and a Newtonian fluid [31]. The Reynolds number (Re) of a potential flow in the interstitial spaces is therefore around Re = 10−7 to 10−6, indicating a creeping (Stokes) flow where viscous ...
Although upregulation of these transporters has been demonstrated in clinical studies before, it is not known whether this leads to reduced anti-seizure drug concentrations in interstitial fluid. Rambeck et al. attempted to determine concentrations of antiepileptic drugs in serum, subarachnoid ...
In addition to cushioning the central nervous system, CSF clears waste from the brain. In what's called the glymphatic system, waste products from the interstitial fluid surrounding brain cells move into the CSF and away from the brain, according to theSociety for Neuroscience. Studies suggest th...
Traumatic axonal injury has consistently been reported to activate microglia and inflammatory pathways, both in animal models as well as in human TBI22,55,56, and elevations of pro-inflammatory cytokines and chemokines are observed in serum, CSF and in brain interstitial fluid56. In human brain ...