Decreases inCALB1expression/concentration in brain tissue has been associated with neurodegeneration in Alzheimer’s, Parkinson’s, and Huntington’s diseases [18,65] and in ischemic injury studies [66,67]. LowerCALB1expression has also been associated with a higher rate of neuronal death [68]. ...
maturation and enzymatic activity of a subset of lysosomal cathepsins in microglia and other brain cells. Microglia, which are the main source of PGRN in the brain, showed a severe impairment of lysosomal cathepsin expression and maturation in the absence ...
The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. Reprints and permissions About this article Cite this article Furukawa, E., Shimabukuro, S., Alsop, B. et al. ...
The Creative Commons Public Domain Dedication waiver ( https://creativecommons.org/publicdomain/zero/1.0/ ) applies to the data made available in this article, unless otherwise stated. Reprints and permissions About this article Cite this article Heron, P.M., Stromberg, A.J., Breheny, P. ...