Tyler, 18, looks like an average high-school senior—but spend a few minutes talking with him, and you may notice he has trouble sustaining the discussion. When Tyler was 14, he was the front-seat passenger in a car that hit a tree. Although wearing a seat belt, TylerJ HaarauerKrupa...
50,000 people die yearly from traumatic brain injury. This website is a resource, providing in-depth educational information and research about brain injuries
stroke (N = 5) and hypoxia (N = 1), with an average GCS of 4.1 at the time of injury. Ten of the 13 participants had a score of 1 on each of the cognitive, communication and mobility domains
ArticlePubMedPubMed CentralGoogle Scholar Alexander GE, DeLong MR, Strick PL. Parallel organization of functionally segregated circuits linking basal ganglia and cortex. Ann Rev Neurosci. 1986.https://doi.org/10.1146/annurev.ne.09.030186.002041. Haber SN. Corticostriatal circuitry. Dial Clin Neurosci....
GC is supported by the DBT/Wellcome Trust India Alliance Fellowship/Grant IA/I(S)/17/1/503085. HJB is supported by NIH grants R01AG07326 and U01AG072439. Support of instrumentation for the Orbitrap Eclipse Tribrid from the NCRR shared instrumentation grant 1S10 OD028654, awarded to BS. ...
Acquired brain injury (ABI) is defined as an acute neurological insult that involves a number of conditions and etiologies, such as traumatic brain injury, cardiovascular accident, and hypoxia, among others [1,2]. The consequences are complex and often multifaceted and can involve motor, cognitive...
Finally, we investigated toxicity from v3em PE3-AAV delivery by measuring serum alanine aminotransferase (ALT) and aspartate transaminase (AST) levels, biomarkers of hepatocellular and kidney injury89. We used v3em PE3-AAV8, a serotype that efficiently and specifically transduces murine hepatocytes90...
; all share the risk of injury, maiming and death along with the trigger-pullers and Special Ops troops. Everyone shares in the risk in this war; everyone knew that risk when they signed up. That, to me, is the essence of what a hero is—doing the right thing despite the knowledge...
Previous studies have demonstrated that intravitreal delivery of brain-derived neurotrophic factor (BDNF) by injection of recombinant protein or by gene therapy can alleviate retinal ganglion cell (RGC) loss after optic nerve injury. BDNF gene therapy can improve RGC survival in experimental models of...
Restoration of Shh signaling by SAG leads to rescue of BBB function in HIV-infected, human- ized mice. We asked whether fortification of BBB function via restoration of Shh signaling prevents CNS injury. To test this notion, Smo agonist, SAG, was administered to HIV infected mice. This ...