The optimal arterial blood pressure target after cardiac arrest to mitigate PCABI from secondary ischemic injury is not known. In 2019, the Neuroprotect trial [23] randomised 107 comatose patients resuscitated from cardiac arrest to undergo either protocolised goal-directed haemodynamic optimisation (me...
Intensive care for brain injury after cardiac ar- rest: Therapeutic hypothermia and related neurop- rotective strategies. Crit Care Clin 2007;22:619-36.Geocadin RG; Koenig MA; Stevens RD;.Intensive care for brain injury after cardiac arrest: therapeutic hypothermia and related neuropretective ...
Brain injury after cardiac arrest: pathophysiology, treatment, and prognosis 来自 Semantic Scholar 喜欢 0 阅读量: 204 作者:C Sandroni,T Cronberg,M Sekhon 摘要: Intensive Care Medicine - Post-cardiac arrest brain injury (PCABI) is caused by initial ischaemia and subsequent reperfusion of the ...
Translational approach to assess brain injury after cardiac arrest in preclinical models: a narrative review doi:10.1186/s40635-024-00710-ySpringer International PublishingIntensive Care Medicine ExperimentalFrancesca MottaDepartment of Acute Brain and Cardiovascular Injury Istituto di Ricerche Farmacologiche ...
Mechanisms of brain injury after global cerebral ischemia. Neurol. Clin. 24, 1–21 (2006). Article PubMed Google Scholar Sekhon, M. S., Ainslie, P. N. & Griesdale, D. E. Clinical pathophysiology of hypoxic ischemic brain injury after cardiac arrest: a “two-hit” model. Crit. Care...
Secondary injury is a major determinant of outcome in hypoxic ischemic brain injury (HIBI) after cardiac arrest and may be mitigated by optimizing cerebral oxygen delivery (CDO2). CDO2is determined by cerebral blood flow (CBF), which is dependent upon mean arterial pressure (MAP). In health,...
Primary vs secondary injury Primary braininjuryis the injury sustained at the time of impact.Public healthmeasures prevent primaryinjuries, but medical management can do little to reverse them. Secondary brain injuryis any injury that occurs after the primary and hence should be preventable or at le...
4 Small observational studies have found that blood-based brain injury biomarkers may be associated with outcomes after pediatric cardiac arrest.5,6 The brain-specific biomarkers ubiquitin carboxyl-terminal esterase L1 (UCH-L1) and glial fibrillary acidic protein (GFAP) have been approved by the US...
For patients with cardiac and respiratory arrest, it is better to rescue them in hyperbaric oxygen chamber. This video shows a critically ill patient in a deep coma, no breathing, whose blood pressure needs to be maintai...
Ac2-26 Alleviates Brain Injury after Cardiac Arrest and Cardiopulmonary Resuscitation in Rats via the eNOS Pathway Background: Brain injury is the leading cause of death following cardiac arrest (CA) and cardiopulmonary resuscitation (CPR). Ac2-26 and endothelial nitric oxide synthase (eNOS) have ...