Brain Disorders, Dysfunctions, and Natural Selection: Commentary on JeffersonI argue that despite the merits of Jefferson's account of a brain disorder, which are many, the notion of function she deploys is unsuitable to the overall goals of that account. In particular, Jefferson accepts Cummins...
Minimal brain dysfunction (MBD) has become an important diagnostic label for the disorders in many children who exhibit certain constellations of learning and behavior problems. There remains, however, considerable misunderstanding about the meaning and the applicability of this term. The disagreements abo...
While no intellectual deficits were found, subjects displayed poor sustained attention and concentration and had difficulty changing from one working method to another and abstracting from simple sensory ideas. In addition to the motor and perceptuomotor dysfunctions, two other characteristics sto...
The present study aimed at identifying dysfunctions in brain networks that may underlie disturbed empathic behavior in autism spectrum disorders (ASD). During functional magnetic resonance imaging, subjects were asked to identify the emotional state observed in a facial stimulus (other-task) or to eval...
Park C, Park SK. Molecular links between mitochondrial dysfunctions and schizophrenia. Mol Cells. 2012;33:105–10. ArticleCASPubMedPubMed CentralGoogle Scholar Park HJ, Choi I, Leem KH. Decreased brain pH and pathophysiology in schizophrenia. Int J Mol Sci. 2021;22:8358. ...
temporal resolution alongside deep characterization of the environment are needed to better understand the seasonal adaptions of the human brain as a function of age, sex, and geographic latitude and to investigate the mechanisms underlying the alterations in seasonal adaptation in psychiatric disorders....
type dopamine neuron degeneration, pathological α-synuclein aggregation, an increase in intrinsic neuronal firing frequency, and mitochondrial and lysosomal dysfunctions were detected [115]. ALS is a neurodegenerative disease specifically affecting motor neurons; it typically results in progressive muscle ...
摘要: ▶Emotion-processing and cognitive-control regions affect negative cognitive bias. ▶Depressed patients showed dysfunctions in the right amygdala and the right dorsolateral prefrontal cortex. ▶A significant correlation was found between the two regions....
Microvascular and cellular dysfunctions in Alzheimer’s disease: an integrative analysis perspective Article Open access 09 September 2024 References Iadecola, C. The neurovascular unit coming of age: a journey through neurovascular coupling in health and disease. Neuron 96, 17–42 (2017). Article...
whereas distinct relationships between right prefrontal GI and cognitive subdomains by each disorder can reflect a set of discrete dysfunctions135. Thus, further studies are required to examine which hypotheses explain the associations between anomalous patterns of focal gyrification and cognitive impairments...