In general, this system stimulates tissue metabolism, increases alertness, and prepares the individual for sudden, intense physical activity ("fight or flight" response). When this entire division responds, the effects are felt as increased alertness, a feeling of energy and euphoria, increased cardi...
In the approach, we employ the coefficient of variance statistically to determine the dual thresholds in the intensities of grey matter and white matter, and then use them to obtain preliminary thresholded masks, which consist of some non-brain tissues on skull. Different from other popular ...
which could theoretically allow high-spatial resolution imaging of the entire brain. We focused on the cerebellum due to its well-defined cellular composition and laminar organization, where the Purkinje cell layer is flanked by molecular and granular layers14(Supplementary Fig.4a). Biologically...
Knowing one’s own behavioral state has long been theorized as critical for contextualizing dynamic sensory cues and identifying appropriate future behaviors. Ascending neurons (ANs) in the motor system that project to the brain are well positioned to pr
Please read Elsevier’s author policy on the use of generative AI and AI-assisted technologies, which can be found in our GenAI Policies for journals. Please note: to protect authors’ rights and the confidentiality of their research, this journal does not currently allow the use of generative...
An idea is not a replicator because it does not consist of coded self-assembly instructions. It may retain structure as it passes from one individual to a... L Gabora - 《Biology & Philosophy》 被引量: 171发表: 2004年 The cobra head sign Unlike the deadly reptile for which it is name...
led to the implementation of standards for new models. The drug delivery field has been developing for 3 decades but has fallen short of its potential. This shortcoming can be explained by the duality faced by this field: when the tissue is available, the conservative approach works and the ...
Mice in which NET was removed showed decreased NE tissue concentrations in various brain areas, decelerated NE clearance after activation of noradrenergic neurons, and an increased response to behavioral despair (Xu et al.2000). DAT participates in the regulation of DA neurotransmission that is ...
Achieving brain-wide coverage and cell-specific profiling requires probing a large number of tissue sections and cells (Fig. 1a), which is time-prohibitive on high-mass-resolution platforms such as FT-ICR (Methods,‘Signal modeling’). To this end, we developed a deep-learning model to ...
Previous studies on Parkinson’s disease mechanisms have shown dysregulated extracellular transport of α-synuclein and growth factors in the extracellular space. In the human brain these consist of perineuronal nets, interstitial matrices, and basement