et al. Restoration of brain circulation and cellular functions hours post-mortem. Nature 568, 336–343 (2019). This study shows that circulation and cellular functions can be restored in the post-mortem large mammalian brain up to 4h after death using appropriate multimodal interventions. Article ...
Chemicals, peptides, and recombinant proteins Fentanyl Sintetica Cat #699811 Midazolam Roche Cat #M-908-1ML Medetomidine Orion Pharma Cat #520370 Buprenorphine Sintetica Human alpha-thrombin Haematologic Techn. Cat #HCT-0020 2,3,5-triphenyltetrazolium chloride Sigma-Aldrich Cat. #T8877 Actilyse®...
The innate and adaptive immune responses play an important role in the pathogenesis of TBI. Gamma-delta (γδ) T cells have been shown to affect brain immunopathology in multiple different conditions, however, their role in acute and chronic TBI is largely unknown. Here, we show that γδ T...
All other chemicals and solvents were of analytical grade. Animals The present study complied with the Guide for the Care and Use of Laboratory Animals published by the National Institutes of Health (NIH publication no. 85-23, revised in 1985), and all the animal experiments were approved by...
Stroke attracts neutrophils to the injured brain tissue where they can damage the integrity of the blood–brain barrier and exacerbate the lesion. How
Together, the above findings indicate that distinct sensory neurons, which innervate different organs/tissues of the GI tract, respond to different gut-derived signals and that their neuronal activation contributes to the regulation of feeding and glucose metabolism. In agreement with this, recent imagi...
Glioblastoma multiforme (GBM) is the most common and malignant of all human primary brain cancers, in which drug treatment is still one of the most effective treatments. However, existing drug discovery and development methods rely on the use of conventi
Yes, their hearts needed to beat and their lungs needed to breathe, but mammals were about a lot more than survival functions—they were in touch with complex feelings like love, anger, and fear. For the reptilian brain, which had only had to deal with reptiles and other simpler creatures...
endocrine system. Your Hypothalamus, which controls your pituitary gland, is more than capable of producing all the chemicals (hormones and neurotransmitters) you need, but can also produce too much or too little leading to stress, anxiety, inflammation, cancer, reproductive disorders and poor ...
2.2. Chemicals, reagents, and tissues All chemicals used in the study were supplied by SigmaeAldrich (St. Louis, MO) unless otherwise specified. All cell culture reagents were supplied by Life Technol- ogies (San Diego, CA) unless otherwise specified. All animals used for the production...