who has turned skin cells into medium spiny neurons (MSNs), the cells that go wrong in Huntington's disease. To the human skin cells, Yoo's team added two short snippets of genetic material called microRNAs - the two they picked turn on genes in brain cells during embryonic development. ...
Skin cells were donated from patients at the UCI Alzheimer's Disease Research Center. The study, led by Edsel Abud, Wayne Poon and Mathew Blurton Jones of UCI, used a genetic process to reprogram these cells into a pluripotent state capable of developing into any type of cell or tissue of...
Primitive macrophages start to populate the neuroectoderm of the murine fetus through the blood circulation at embryonic day (E) 8.5 and remain the only glial cells until the prebirth fetal stage, when astrocytes and oligodendrocytes emerge (Fig. 2). Interestingly, microglia differ in males and ...
For example, expression of the 30UTRs of prohibitin, Pea-15, and troponin1 had been previously described to influence proliferation and differentiation of cancer and muscle cells, respectively (Jupe et al, 1996; Rastinejad et al, 1993; Tsukamoto et al, 2000). Several of the predicted miRNA-...
contributes to the process of sexual differentiation is illustrated by studies of the neural song circuit in a gynandromorphic zebra finch, where genetically male and female brain cells develop differently in the presence of the same levels of circulating gonadal hormones [7]....
There is a functional device in embryonic ectodermal cells that we propose causes them to differentiate into either neuroepithelial or epidermal tissue dur
Cells were gated using FSCA and FSCH to identify singlets, then gated for live cells by taking a population that was negative for live/dead stain. Gating strategy is presented in Figure S1J. Eyes were not pooled together for analysis. Intracerebral Administration of Pseudomonas aeruginosa Mice ...
A simple zap from a small chip could be enough to reprogram skin cells to perform other valuable functions, like carrying blood or even helping you think.
Mesenchymal stem cells (MSCs), as cell-based therapy offer a potential source of therapies for various rodent models and clinical trials of human diseases such as Parkinson's disease, Huntington's disease, myocardiac infarction, and stroke (5–9). However, limited data are available in neonatal...
In vivo—“within the living”; experiment conducted on or in whole living organisms/cells. Electrical conductivity values obtained within a living head were considered in vivo. Ex vivo—“out of the living”; experiment in or on tissue from an organism in an external environment, but with min...