A laser probe has been used to open the brain’s protective cover, enabling delivery of chemotherapy drugs to patients with glioblastoma — the most common and aggressive form of brain cancer. In a pilot study conducted by the Washington University School of Medicine in St. Louis, Mo., 14...
(Washington University, St. Louis, MO). Genotyping of mice was performed using PCR and primers for TSC1 and CRE according to the procedure provided by Dr. Wong. Kits were purchased from Lambda Biotech (catalog number D124R). All mice were acclimated to the environment, examined, handled, ...
To establish appropriate controls and analyses for future clinical studies, here we analyze data collected from healthy individuals (N = 62) as part of the Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network. Participants orally ingested approximately 350 mL of...
Metabolomics and cancer drug discovery: let the cells do the talking. Drug Discov Today. 2012;17(1–2):3–9. Article PubMed Google Scholar Beyoglu D, Idle JR. Metabolomics and its potential in drug development. Biochem Pharmacol. 2013;85(1):12–20. Article CAS PubMed Google Scholar ...
Drug sessions were facilitated by two clinical research staff who completed an approved in-person or online facilitator training programme provided by Usona Institute, as part of the phase 2 study (ClinicalTrials.gov identifier NCT03866174). The role of the study facilitators was to build a therape...
Targeted imaging and therapy of brain cancer using theranostic nanoparticles. Mol Pharm. 2010;7(6):1921–9. https://doi.org/10.1021/mp100298r. Article CAS PubMed PubMed Central Google Scholar Cunha S, Amaral MH, Lobo JMS, Silva AC. Lipid nanoparticles for nasal/intranasal drug delivery. ...
Department of Neurology, Washington University School of Medicine, St Louis, MO, USA David F. Montez, Benjamin P. Kay, Ryland L. Miller, Dillan J. Newbold, Annie Zheng, Nicole A. Seider, Andrew N. Van, Athanasia Metoki, Roselyne J. Chauvin, Steven E. Petersen & Nico U. F. Dosenbac...
Each trial terminated once the mouse reached the platform within a cut-off time of 60 s, and the average escape latency of the four trials for each mouse was calculated. On the sixth day of the test, the platform was removed. Each mouse was placed into the SE quadrant and was allowed ...
Gilbert MR et al (2003) Phase I clinical and pharmacokinetic study of irinotecan in adults with recurrent malignant glioma. Clin Cancer Res 9(8):2940–2949 CAS PubMed Google Scholar Glantz MJ, Cole BF, Friedberg MH, Lathi E, Choy H, Furie K, Akerley W, Wahlberg L, Lekos A, Louis ...
Department of Pathology and Immunology, Washington University in St Louis, School of Medicine, St Louis, MO, USA Justin Rustenhoven & Jonathan Kipnis Department of Pharmacology and Clinical Pharmacology, The University of Auckland, Auckland, New Zealand ...