This study aimed to investigate the cerebral atrophy pattern in cognitive impairment associated with late-onset depression and to preliminary examine whether there are common or distinct mechanisms involved in the associations between depression and mild cognitive impairment. Methods: Nine patients with ...
Association between anticholinergic medication use and cognition, brain metabolism, and brain atrophy in cognitively normal older adults. JAMA Neurol. 2016;73(6):721–32. Article PubMed PubMed Central Google Scholar Kersten H, Molden E, Tolo IK, et al. Cognitive effects of reducing ...
Another pathology finding showed that hippocampal atrophy and demyelination were related to the increasing severity of OSA [68]. One possible explanation for these inconsistent results could account for different image analysis tools and statistical thresholds. It has been reported that the whole-brain ...
ALS is a neurodegenerative disease specifically affecting motor neurons; it typically results in progressive muscle atrophy and usually death from respiratory failure [92,116]. Cultured motor neurons from ALS patients show degeneration, abnormal protein aggregation, and increased cell death [117,118]. G...
From the ~43 K UK Biobank participants who had been scanned, we searched for those who had been diagnosed with Alzheimer’s disease specifically, regardless of whether this diagnosis occurred before, or after their brain scans. Based on hospital inpatient records (ICD10: F000, F001, F002, ...
(when the brain bounces back and forth or sideways within the cranium). TBI seldom affects a single area of the brain and often leads to diffuse damage which explains the multitude of physical, social, cognitive, and psychiatric symptom presentations postinjury.Cerebral atrophyhas been observed up...
The APOEε4 allele is associated with cognitive deficits and brain atrophy in older adults, but studies in younger adults are mixed. We examined APOE genotype effects on cognition and brain structure in younger adults and whether genotype effects differed by age and with presence of depression. 15...
Our genetic results from GM-BAG substantiate that many diseases, conditions, and clinical phenotypes share genetic underpinnings with brain age, perhaps driven by macrostructural changes in GM (e.g., brain atrophy). The locus with the most significant signal (the top lead SNP rs534114641 at 17...
The morphometric co-atrophy networking of schizophrenia, autistic and obsessive spectrum disorders. Hum. Brain Mapp. 39, 1898–1928 (2018). Article PubMed PubMed Central Google Scholar Raj, A. & Powell, F. Models of network spread and network degeneration in brain disorders. Biol. Psychiatry ...
43 Moreover, the evidence that substance misuse can lead to GM atrophy in the insula is inconsistent.116,117 No structural differences were observed between the offenders with ASPD+P and those with ASPD−P and the healthy nonoffenders in either the amygdala or the vmPFC. Abnormalities of ...