BR96-Dox is an immunoconjugate (IC) in which doxorubicin (8 equivalents) is linked via an acid-labile hydrazone to the chimeric MAb BR96. It binds to a modified Ley Ag on tumor cells, which then internalize it via endocytosis into lysosomes. There, the acidic milieu hydrolyzes the ...
The toxicity of BMS-182248, an immunoglobulin (cBR96)-cytotoxic drug () conjugate, was investigated in at single intravenous doses of 508, 1,200, and 2,550 mg/m2 (conjugated doses of 14.7, 34.8, and 74 mg/m2, respectively) and compared to that obtained from administration of free at ...
Immunoconjugates (BR96-DOX) were prepared between chimeric monoclonal antibody BR96 and the anticancer drug doxorubicin. The monoclonal antibody binds an antigen related to Lewis Y that is abundantly expressed at the surface of cells from many human carcinomas; it has a high degree of tumor selec...
中文名称: BR96-doxorubicin immunoconjugate 中文同义词: 英文名称: BR96-doxorubicin immunoconjugate 英文同义词: BR96-doxorubicin immunoconjugate CAS号: 分子式: 分子量: 0 EINECS号: Mol文件: Mol File BR96-doxorubicin immunoconjugate 信息错误报告 提交 按省份浏览BR96-doxorubicin immunoconjugate供应...
(MoAbs)thatbindtotumor-associ-atedantigens,displaydifferenttoxicityprofilescomparedwithradiolabeledMoAbs.Dose-limitingtoxicitiesmayincludedamagetotheliverandmyelotoxicity.Thedrugcomponentistheantimitoticagentauristatin,whichis100-1000timesmorepotentthandoxorubicin.Consequently,auristatinantibody-drugconjugatesrequireahigh...
Cure of xenografted human carcinomas by BR96-doxorubicin immunoconjugates. Science. 1993;261:212-5.Trail PA, Willner D, Lasch SJ, et al. Cure of xenografted human carcinomas by BR96-doxorubicin immunoconjugates. Science 1993; 261:212-5....