支气管肺发育不良(bronchopulmonary dysplasia,BPD)为一类由多种因素和机制引起的早产儿常见慢性呼吸系统疾病,这类患儿生后需接受氧疗或通气治疗。近年来随着围产期医疗技术水平的提高,早产及极低出生体重儿救治成功率越来越高,BPD发生率也随之升高,...
Hansmann G, Sallmon H, Felderhoff-Müser U, Witt S, Schwettmann L, Hilgendorff A. Current diagnosis and treatment practice for pulmonary hypertension in bronchopulmonary dysplasia-A survey study in Germany (PUsH BPD). ...
We have used mesenchymal stem cells in preclinical models of pulmonary hypertension (PH) and in the hyperoxia-induced neonatal murine model of bronchopulmonary dysplasia (BPD) to suppress inflammation and improve survival while attenuating alveolar injury and PH. The protective effect was predominantly ...
不同程度的BPD肺部病理生理和呼吸力学差异显著,sBPD常伴有生长迟缓、肺动脉高压(pulmonary hypertension,PH)、气管-支气管软化、胃食管反流和反复微吸入、气道高反应性等,使呼吸支持和氧需求难以降低,因此需要个体化管理方案。 sBPD患儿肺部过度膨胀和肺不张区域常交错存在,气道阻力明显升高,通气死腔显著增加,这样的患儿...
[27]KINSELLA J P,STEINHORN R H,KRISHNAN U S,et al.Recommendations for the use of inhaled nitric oxide therapy in premature newborns with severe pulmonary hypertension[J].J Pediatr,2016,170:312-314. [28]ELBERS L P B,FLIERS E.The influence ofthyroidfunction on the coagulation system and its...
4. Choi EK, Jung YH, Kim HS, et al. The impact of atrial leftto-right shunt on pulmonary hypertension in preterm infants with moderate or severe bronchopulmonary dysplasia [J]. Pediatr Neonatol, 2015, 56(5): 317-323 5. Schmidt B et al. N Engl J Med. 2006 May 18;354(20):2112-...
Objective This study aimed to establish a neonatal rat model of bronchopulmonary dysplasia( BPD) complicated by pulmonary hypertension( PH) high-low oxygen... 邢玉娇,衣曼,富建华,... - 《Journal of China Medical University》 被引量: 0发表: 2020年 加载更多来源...
and subspecialty care to maintain health. Although advances in neonatal and pulmonary care have improved overall survival, earlier gestational age, lower birth weight, chorioamnionitis and late onset sepsis continue to be major factors in the development of bronchopulmonary dysplasia. These early life ...
Treatment of newborn rats with a VEGF receptor inhibitor causes pulmonary hypertension and abnormal lung structure To determine whether disruption of vascular endothelial growth factor (VEGF)-VEGF receptor (VEGFR) signaling in the newborn has long-term effects on lung s... TDL Cras,NE Markham,RM...
BPD的病理特征是肺泡与肺血管的发育障碍,由此引起病理生理改变,主要包括:肺顺应性降低、潮气量和功能残气量减少、死腔增加;气道阻力和呼吸功增加;通气/血流比值失调,气体交换面积减少,引起低氧血症和二氧化碳潴留;肺血管床减少,肺血管重建,最终导致肺...